神戸大学附属図書館デジタルアーカイブ
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https://doi.org/10.24546/00098320
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2024-03-29
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00098320 (fulltext)
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1.46 MB
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メタデータID
00098320
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open access
出版タイプ
Version of Record
タイトル
Beta Integrins (α4β1, α5β1) and Matrix Metalloproteinases Expression in Synovial Pannus Formation in Rheumatoid Arthritis
著者
Ishikawa, Hitoshi ; Hirata, Souichirou ; Saura, Ryuichi ; Andoh, Yoshihiro ; Imaizumi, Yasuhiko ; Mizuno, Kosaku
著者名
Ishikawa, Hitoshi
著者名
Hirata, Souichirou
著者名
Saura, Ryuichi
著者名
Andoh, Yoshihiro
著者名
Imaizumi, Yasuhiko
著者名
Mizuno, Kosaku
収録物名
Bulletin of health sciences Kobe
巻(号)
16
ページ
21-30
出版者
Graduate School of Health Sciences, Kobe University
刊行日
2000-12-27
公開日
2006-09-11
注記
本文ファイルは、国立情報学研究所CiNiiより提供されたものです。
抄録
To investigate the mechanism of synovial pannus formation in rheumatoid arthritis, immunohisochemical studies with monoclonal antidodies against the adhesion molecules, α4β1, α5β1 integrins and matrix metalloproteinases (MMP-1, MMP-3) and tissue inhibitor of metalloproteinase (TIMP-1), were carried out to determine the pattern of the distribution of these molecules at the rheumatoid synovial carilage junction. Treatment with purified anti-human monoclonal anti-bodies, anti-α4β1 and α5β1, resulted in membrane staining of most of the cells infiltrating the synovial tissue and bordering the pannus cartilage junction. The α4β1 and α5β1 interaction appeared to be involved in the attachment of the pannus. Staining for MMP-1 and MMP-3 was particularly intense at the pannus-cartilage junction. These molecules were also strongly stained in the cartilage matrix bordering the tip of pannus invasion. TIMP-1 staining disclosed very weak cellular staining and weak extracellular staining at the pannus-cartilage junction. The present study indicates that a receptor-ligand interaction between β1 integrin and cartilage matrix may occur at the early stage of pannus formation, and that this is followed by elevated proteolytic activity of MMPs and a decreased level of TIMP-1. And in this way, these changes may contribute to pannus invasion and cartilage destruction.
キーワード
Synovial-pannus formation
β1 integrins
Matrix metalloproteinases (MMP-1, MMP-3)
Tissue inhibitor of metalloproteinase (TIMP-1)
カテゴリ
Bulletin of health sciences Kobe
>
16号(2000-12-27)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
1346-8707
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AA11316362
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関連情報
NAID
110004599684
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