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https://doi.org/10.24546/00098334
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2024-03-29
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00098334 (fulltext)
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メタデータID
00098334
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open access
出版タイプ
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タイトル
The Relation of 5'flanking Region of the Apolipoprotein(a) Gene to Serum Lipoprotein(a) Level
著者
Shimizu, Hiroshi ; Taniguchi, Takahiro ; Fujioka, Yoshio ; Takahashi, Akihiro ; Ishikawa, Yuichi ; Yokoyama, Mitsuhiro
著者名
Shimizu, Hiroshi
著者名
Taniguchi, Takahiro
著者名
Fujioka, Yoshio
著者名
Takahashi, Akihiro
著者名
Ishikawa, Yuichi
著者名
Yokoyama, Mitsuhiro
収録物名
Bulletin of health sciences Kobe
巻(号)
17
ページ
51-61
出版者
Graduate School of Health Sciences, Kobe University
刊行日
2001-11-30
公開日
2006-09-11
注記
本文ファイルは、国立情報学研究所CiNiiより提供されたものです。
抄録
Lipoprotein(a) (Lp(a)) is an atherogenic lipoprotein whose serum concentration is considered to be mainly determined by apolipoprotein(a) (apo(a)) size and its production rate. Three types, of variation have been identified in the apo (a) gene; a size polymorphism in the coding region, a pentanucleotide repeat polymorphism. In the promoter region, and sequence variation in coding and non-coding regions of the gene including a C/T polymorphism at +93 from the transcription start. To clarify if the analysis of these polymorphisms could predict the serum levels of Lp(a), we subcloned the 1.4 kb 5'flanking region of apo(a) gene from subjects with low (≦10 mg/dl, n=2) and high (> 100 mg/dl, n=3) serum levels of Lp(a) and compared the promoter activity by in vitro transcription assay with HepG2 cells and furthermore studied the response of interleukin-6 and estradiol which had been reported to alter serum levels of Lp(a). Every subject in our study showed C at +93. The basal promoter activity of high Lp(a) group was not higher than that of low Lp(a) group. We did not find that. A size polymorphism and pentanucleotide repeat polymorphism in this region affected the promoter activity. Interleukin-6 had a tendency to enhance the promoter activity, but estradiol did not. In conclusion, serum level of Lp(a) in individual was not predicted by the analysis of polymorphisms of 1.4 kb 5'flanking region of apo(a) gene. There may be other factors. That are responsible for the regulation of the concentration of serum levels of Lp(a).
キーワード
Lipoprotein(a)
Apolipoprotein(a)
5'flanking Region
Polymorphism
カテゴリ
Bulletin of health sciences Kobe
>
17号(2001-11-30)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
1346-8707
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AA11316362
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関連情報
NAID
110004599721
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