神戸大学附属図書館デジタルアーカイブ
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https://doi.org/10.24546/81000143
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2024-04-20
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81000143 (fulltext)
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メタデータID
81000143
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open access
出版タイプ
Version of Record
タイトル
Measurement of Platelet-derived Microparticle Levels in the Chronic Phase of Cerebral Infarction Using an Enzyme-linked Immunosorbent Assay
著者
Shirafuji, Toshihiko ; Hamaguchi, Hirotoshi ; Kanda, Fumio
著者名
Shirafuji, Toshihiko
著者名
Hamaguchi, Hirotoshi
著者名
Kanda, Fumio
収録物名
The Kobe journal of the medical sciences
巻(号)
54(1)
ページ
55-61
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2008
公開日
2008-02-20
抄録
Assessment of platelet function is a critical component of the treatment andsecondary prevention of cerebral infarction, and measurement of platelet-derivedmicroparticle (PDMP) levels using flow cytometry may be a good indicator of plateletfunction. However, the flow cytometric analysis is not feasible in a variety of clinicalsituations. The goal of the present study was to measure PDMP levels using anenzyme-linked immunosorbent assay (ELISA) in chronic cerebral infarction patientsand to determine the utility of PDMP level measurement for the monitoring of theeffect of cilostazol and aspirin.A crossover study was performed using 4-weeks of aspirin (100 mg/day) and4-weeks of cilostazol (200 mg/day) in 18 patients. PDMP levels were also measured in 20volunteers as controls. Experiments demonstrated that PDMP levels were significantlyhigher in chronic cerebral infarction patients (median 8.8 U/ml, interquartile range5.1-14.9 U/ml, n=18) than in controls (median 5.5 U/ml, interquartile range 5.0-8.2 U/ml,n=20) (P=0.047). PDMP levels did not decrease after therapy with either aspirin(median 10.9 U/ml, interquartile range 6.2-17.9 U/ml, n=12) or cilostazol (median 9.2U/ml, interquartile range 6.1-14.3 U/ml, n=12) compared with baseline PDMP levels inthe 12 patients who completed this trial (median 11.4 U/ml, interquartile range 5.2-23.7U/ml, n=12). There were no significant differences in PDMP levels between aspirin andcilostazol (P=0.61). In conclusion, PDMP levels as measured by ELISA were increasedin patients with chronic cerebral infarction regardless of the anti-platelet therapy. Thismethodology may be a useful strategy of assessing platelet function in chronic cerebralinfarction patients.
キーワード
platelet-derived microparticle
ELISA
cerebral infarction
chronic phase
anti-platelet therapy
カテゴリ
The Kobe journal of the medical sciences
>
54巻
>
54巻1号(2008)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
0023-2513
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NCID
AA00711740
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関連情報
NAID
110006648233
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URI
http://www.med.kobe-u.ac.jp/journal/contents.html
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