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https://doi.org/10.24546/81002144
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2024-03-29
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81002144 (fulltext)
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メタデータID
81002144
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open access
出版タイプ
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タイトル
Less stimulating environmental conditions decrease spatial learning ability and reduce GAP-43 and synaptophysin immunostaining in the hippocampal formation in adult male mice
著者
Miyamoto, Mitsuru ; Sugioka, Kozo ; Arakawa, Takamits ; Kawamata, Toshio ; Miki, Akinori
著者名
Miyamoto, Mitsuru
著者名
Sugioka, Kozo
著者名
Arakawa, Takamits
著者名
Kawamata, Toshio
著者名
Miki, Akinori
収録物名
Bulletin of health sciences Kobe
巻(号)
25
ページ
23-36
出版者
Graduate School of Health Sciences, Kobe University
刊行日
2009
公開日
2010-06-07
抄録
Environmental conditions affect learning ability and cause neuroanatomical alterations of neurons and synapses in the hippocampal formation. We reared male mice in standard, enriched and wheel-running environments (n = 7 in each group) as well as in an impoverished environment (n = 9) for 102 days and compared their spatial learning ability and histochemical expression of growth-associated phosphoprotein (GAP-43) and synaptophysin. Spatial learning ability, as measured by the Morris water maze, decreased significantly in the impoverished environment group and increased significantly in the enriched environment group. The optical density of GAP-43 immunostaining in the stratum lacunosum-moleculare and mossy fiber layer was significantly lower in the impoverished environment group than in the other 3 groups. GAP-43 immunostaining in the mossy fiber layer was significantly more intense in the enriched environment group. Synaptophysin immunostaining in the mossy fiber layer was significantly less intense in the impoverished environment group than in the enriched and wheel-running groups. These findings suggest that non-social and less stimulating environments can reduce spatial learning ability and impair function of the hippocampal formation.
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Bulletin of health sciences Kobe
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25号(2009)
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departmental bulletin paper
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English (英語)
ISSN
1346-8707
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NCID
AA11316362
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NAID
110007579271
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