神戸大学附属図書館デジタルアーカイブ
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https://doi.org/10.24546/81005043
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2024-04-26
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81005043 (fulltext)
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メタデータID
81005043
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open access
出版タイプ
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タイトル
N-terminal Pro-brain Natriuretic Peptide Levels in Monochorionic Diamniotic Twins with Twin-to-twin Transfusion Syndrome Treated by Fetoscopic Laser Photocoagulation
著者
Fujioka, Kazumichi ; Sakai, Hitomi ; Tanaka Satoshi ; Iwatani, Sota ; Wada, Keiko ; Mizobuchi, Masami ; Yoshimoto, Seiji ; Nakao, Hideto
著者ID
A0863
研究者ID
1000020568810
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=61a996a431fe1218520e17560c007669
著者名
Fujioka, Kazumichi
藤岡, 一路
フジオカ, カズミチ
所属機関名
医学部附属病院
著者名
Sakai, Hitomi
サカイ, ヒトミ
著者名
Tanaka Satoshi
タナカ, サトシ
著者ID
A0851
研究者ID
1000000741430
著者名
Iwatani, Sota
岩谷, 壮太
イワタニ, ソウタ
所属機関名
医学部附属病院
著者名
Wada, Keiko
ワダ, ケイコ
著者名
Mizobuchi, Masami
ミゾブチ, マサミ
著者名
Yoshimoto, Seiji
ヨシモト, セイジ
著者名
Nakao, Hideto
ナカオ, ヒデト
収録物名
The Kobe journal of the medical sciences
巻(号)
59(1)
ページ
28-35
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2013
公開日
2013-06-04
抄録
Twin-to-twin transfusion syndrome (TTTS) affects 15% of monochorionic diamniotic (MD) twin pregnancies, and is associated with adverse perinatal outcome. Recently, fetoscopic laser photocoagulation (FLP) has been widely accepted as the most definitive therapy to treat TTTS. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a powerful diagnostic marker of cardiac dysfunction in neonates, and is elevated in MD twins with TTTS. However, there are no reports assessing the effect of FLP on neonatal cardiac overload in TTTS by measuring the serum NT-proBNP levels at birth. Here, we aimed to compare serum NT-proBNP levels at birth in MD twins with TTTS treated with FLP or not. Twelve MD twin pairs with TTTS admitted to our center between October 2007 and September 2012 were enrolled in this study. The MD twin pairs were separated into two groups: seven twins (12 newborn infants) with FLP (FLP group) and five twins (nine newborn infants) without FLP (non-FLP group). Gestational age, birthweight, and Apgar scores were significantly higher in the FLP group than that in the non-FLP group. Serum NT-proBNP levels at birth were significantly lower in the FLP group than in the non-FLP group [1425 pg/ml (range, 466–9560) vs. 29900 pg/ml (range, 7300–77900), respectively; p=0.0003]. The serum NT-proBNP levels of larger and smaller co-twins were significantly correlated with each other (r=0.750; p=0.026). In conclusion, serum NT-proBNP levels at birth are lower in MD twins with TTTS after FLP treatment than in those without FLP.
カテゴリ
医学部附属病院
The Kobe journal of the medical sciences
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59巻
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59巻1号(2013)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
0023-2513
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NCID
AA00711740
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URI
http://www.med.kobe-u.ac.jp/journal/contents.html
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