神戸大学附属図書館デジタルアーカイブ
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https://doi.org/10.24546/81005262
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2024-04-24
09:09 集計
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81005262 (fulltext)
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81005262
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open access
出版タイプ
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タイトル
Myocardial Impairment Detected by Late Gadolinium Enhancement in Hypertrophic Cardiomyopathy: Comparison with 99mTc-MIBI/Tetrofosmin and 123I-BMIPP SPECT
著者
Hashimura, Hiromi ; Kiso, Keisuke ; Yamada, Naoaki ; Kono, Atsushi ; Morita, Yoshiaki ; Fukushima, Kazuto ; Higashi, Masahiro ; Noguchi Teruo ; Ishibashi-Ueda, Hatsue ; Naito, Hiroaki ; Sugimura, Kazuro
著者名
Hashimura, Hiromi
著者名
Kiso, Keisuke
著者名
Yamada, Naoaki
著者名
Kono, Atsushi
著者名
Morita, Yoshiaki
著者名
Fukushima, Kazuto
著者名
Higashi, Masahiro
著者名
Noguchi Teruo
著者名
Ishibashi-Ueda, Hatsue
著者名
Naito, Hiroaki
著者名
Sugimura, Kazuro
収録物名
The Kobe journal of the medical sciences
巻(号)
59(3)
ページ
81-92
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2013
公開日
2013-07-24
抄録
Purpose: Myocardial fibrosis is considered to be an important factor in myocardial dysfunction and sudden cardiac death in hypertrophic cardiomyopathy (HCM). The purpose of this study was to compare myocardial fibrosis detected by late gadolinium enhancement (LGE) on cardiac MRI with myocardial perfusion and fatty acid metabolism assessed by single photon emission computed tomography in HCM.Materials and Methods: We retrospectively evaluated 20 consecutive HCM patients (female, 7; mean age, 53.4 years) who underwent LGE, technetium-99m methoxyisobutylisonitrile/tetrofosmin (99mTc-MIBI/tetrofosmin), and iodine-123 beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) imaging. We calculated the myocardium-to-lumen signal ratio (M/L) for LGE in 17 segments based on the American Heart Association statement. Scoring of 99mTc-MIBI/tetrofosmin (PI) and 123I-BMIPP (BM) was performed for each segment using a 5-point scale (0, normal; 4, highly decreased).Results: Nineteen of 20 patients (95%) and 153 of 340 segments (45%) showed LGE. M/Ls were 0.42ア・.16, 0.55ア・.17, and 0.65ア・.24 in PI0/BM0, PI0/BM1-4 and PI1-4/BM1-4, respectively. All M/Ls were significantly higher than that of a normal control (0.34ア・.14) (p<0.001).Conclusions: Myocardial fibrosis in HCM can occur despite normal perfusion and fatty acid metabolism, and is more strongly associated with disorders of fatty acid metabolism than with perfusion abnormalities. M/L may be a useful indicator of disease severity.
カテゴリ
The Kobe journal of the medical sciences
>
59巻
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59巻3号(2013)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
0023-2513
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NCID
AA00711740
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URI
http://www.med.kobe-u.ac.jp/journal/contents.html
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