神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90004197
このアイテムのアクセス数:
11
件
(
2024-04-20
13:43 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90004197 (fulltext)
pdf
2.47 MB
3
メタデータ
ファイル出力
メタデータID
90004197
アクセス権
open access
出版タイプ
Version of Record
タイトル
Acute bout of exercise induced prolonged muscle glucose transporter-4 translocation and delayed counter-regulatory hormone response in type 1 diabetes
著者
Sato, Koji ; Nishijima, Takeshi ; Yokokawa, Takumi ; Fujita, Satoshi
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Nishijima, Takeshi
著者名
Yokokawa, Takumi
著者名
Fujita, Satoshi
収録物名
PLoS ONE
巻(号)
12(6)
ページ
e0178505-e0178505
出版者
Public Library of Science
刊行日
2017-06-01
公開日
2017-09-26
抄録
Previous studies have demonstrated that an acute bout of aerobic exercise induces a subsequent delayed onset of hypoglycemia among patients with type 1 diabetes. However, the mechanisms of exercise-induced hypoglycemia in type 1 diabetes are still unclear. Streptozotocin (STZ) was injected to 6-week-old male Wistar rats, and three days after STZ injection, animals were randomly assigned into 2 groups: STZ with insulin only (STZ) and STZ with insulin and exercise (STZ+EX). Normal Wistar rats with exercise were used as control (CON+EX). Insulin was intraperitoneally injected (0.5 U/kg) to both STZ groups (-0.5 h), and a bout of aerobic exercise (15 m/min for 30 min) was conducted at euglycemic conditions (0 h). Blood was collected at 0, 1, 3, and 5 h after exercise from the carotid artery. While the blood glucose level was stable during the post-exercise period (0-5 h) in the STZ and CON+EX groups, it decreased significantly only in the STZ+EX group at 3 h. Plasma glucagon, adrenalin, and noradrenalin levels significantly increased at 1 h in the STZ group, whereas significant hormonal responses were observed at 5 h in the STZ+EX group. In skeletal muscle glucose metabolism-related pathway, the level of glucose transporter-4 (GLUT-4) translocation was significantly higher at 1 h in the CON and STZ groups. However, in the STZ+EX group, these activations were maintained by 5 h, indicating a sustained glucose metabolism in the STZ+EX group. A single bout of aerobic exercise induced a delayed onset of hypoglycemia in STZ-treated rats. A prolonged enhancement of GLUT-4 translocation and delayed counter-regulatory hormone responses may have contributed to the induction of hypoglycemia.
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2017 Sato et al.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
詳細を表示
資源タイプ
journal article
言語
English (英語)
eISSN
1932-6203
OPACで所蔵を検索
CiNiiで学外所蔵を検索
関連情報
DOI
https://doi.org/10.1371/journal.pone.0178505
ホームへ戻る