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https://hdl.handle.net/20.500.14094/90004214
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2024-04-23
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90004214 (fulltext)
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90004214
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open access
出版タイプ
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タイトル
DHEA administration and exercise training improves insulin resistance in obese rats
著者
Sato, Koji ; Iemitsu, Motoyuki ; Aizawa, Katsuji ; Mesaki, Noboru ; Ajisaka, Ryuichi ; Fujita, Satoshi
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Iemitsu, Motoyuki
著者名
Aizawa, Katsuji
著者名
Mesaki, Noboru
著者名
Ajisaka, Ryuichi
著者名
Fujita, Satoshi
収録物名
Nutrition and Metabolism
巻(号)
9
ページ
47-47
出版者
BioMed Central
刊行日
2012-05-30
公開日
2017-10-10
抄録
Background: Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This study was undertaken to determine whether 6-weeks of DHEA administration and/or exercise training improve insulin resistance in obese male rats. Methods: After 14 weeks of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of four groups: control, DHEA administration, exercise training, and a combination of DHEA administration and exercise training (n = 10 each group). Results: After 6-weeks of DHEA administration and/or exercise training, rats in the combination group weighed significantly less and had lower serum insulin levels than rats in the other groups. Moreover, the rats treated with DHEA alone or DHEA and exercise had significantly lower fasting glucose levels (combination, 84 ± 6.5 mg/dL; DHEA, 102 ± 9.5 mg/dL; control, 148 ± 10.5 mg/dL). In addition, insulin sensitivity check index showed significant improvements in the combination group (combination, 0.347 ± 0.11; exercise, 0.337 ± 0.16%; DHEA, 0.331 ± 0.14; control, 0.308 ± 0.12). Muscular DHEA and 5α-dihydrotestosterone (DHT) concentrations were significantly higher in the combination group, and closely correlated with the quantitative insulin-sensitivity check index (DHEA: r = 0.71, p < 0.01; DHT: r = 0.69, p < 0.01). Conclusion: These results showed that a combination of DHEA administration and exercise training effectively improved fasting blood glucose and insulin levels, and insulin sensitivity, which may reflect increased muscular DHEA and DHT concentrations.
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人間発達環境学研究科
学術雑誌論文
権利
© 2012 Sato et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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資源タイプ
journal article
言語
English (英語)
eISSN
1743-7075
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関連情報
DOI
https://doi.org/10.1186/1743-7075-9-47
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