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https://hdl.handle.net/20.500.14094/90004215
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2024-04-27
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90004215 (fulltext)
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メタデータID
90004215
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open access
出版タイプ
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タイトル
The Exercise-Induced Improvement in hyperglycemia is Mediated by DHT Produced in the Skeletal Muscle of Zucker Diabetic Fatty Rats
著者
Sato, Koji ; Fujita, Satoshi ; Yamauchi, Hideki ; Shiroya, Yoko ; Kitamura, Hiromi ; Minato, Kumiko ; Iemitsu, Motoyuki
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Fujita, Satoshi
著者名
Yamauchi, Hideki
著者名
Shiroya, Yoko
著者名
Kitamura, Hiromi
著者名
Minato, Kumiko
著者名
Iemitsu, Motoyuki
収録物名
Journal of Diabetes and Metabolism
巻(号)
4(1)
ページ
239-239
出版者
OMICS International
刊行日
2013
公開日
2017-10-10
抄録
The ability of exercise to improve hyperglycemia by enhancing glucose metabolism in the skeletal muscle of type 2 diabetic patients is well established. We reported sex steroid hormones can be locally synthesized in skeletal muscle and decrease fasting blood glucose levels in obese rats. Here, we determined whether exercise-induced production of sex steroid hormones in skeletal muscle could directly reverse hyperglycemia in the Zucker diabetic fatty rat model using osmotic mini pump. Thirty Zucker diabetic fatty rats were randomly assigned to the following groups: control, exercise, or exercise with continuous infusion of 5α-reductase inhibitor. The results indicated 6 weeks of exercise significantly reduced serum insulin and fasting glucose levels compared to control group. Dehydroepiandrosterone, 5α-dehydrotestosterone, and 5α-reductase levels were all significantly higher in skeletal muscle of the exercise group. Moreover, exercise increased glucose transporter-4 translocation with a concomitant upregulation of phosphorylated phosphoinositide 3-kinase, protein kinase B and C-ζ/λ. Furthermore, significant correlations were observed between fasting glucose and muscular DHT levels. Interestingly, the observed exercise-induced improvements in serum insulin and fasting glucose levels were all suppressed by administration of 5α-reductase inhibitor. These results indicated the exercise-induced improvements in glucose metabolism signaling and glucose levels may be directly attributed to the increased levels of sex steroid hormones within skeletal muscles.
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人間発達環境学研究科
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© 2013 Sato K, et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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資源タイプ
journal article
言語
English (英語)
eISSN
2155-6156
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DOI
https://doi.org/10.4172/2155-6156.1000239
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