神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90004216
このアイテムのアクセス数:
10
件
(
2024-04-20
14:22 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90004216 (fulltext)
pdf
401 KB
3
メタデータ
ファイル出力
メタデータID
90004216
アクセス権
open access
出版タイプ
Version of Record
タイトル
Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults
著者
Fujie, Shumpei ; Sato, Koji ; Miyamoto-Mikami, Eri ; Hasegawa, Natsuki ; Fujita, Satoshi ; Sanada, Kiyoshi ; Hamaoka, Takafumi ; Iemitsu, Motoyuki
著者名
Fujie, Shumpei
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Miyamoto-Mikami, Eri
著者名
Hasegawa, Natsuki
著者名
Fujita, Satoshi
著者名
Sanada, Kiyoshi
著者名
Hamaoka, Takafumi
著者名
Iemitsu, Motoyuki
収録物名
PLoS ONE
巻(号)
9(4)
ページ
e93545-e93545
出版者
Public Library of Science
刊行日
2014-04-01
公開日
2017-10-10
抄録
Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin regulates endothelial NO synthase in endothelial cells, promoting NO production. However, the effect of aerobic exercise training on circulating apelin levels in healthy middle-aged and older adults remains unknown. Accordingly, this study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects (67.0 ± 1.3 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated plasma apelin and nitrite/nitrate (NOx) concentrations, VO2peak, and arterial stiffness index. In the training group, VO2peak was significantly increased, and carotid β-stiffness was significantly decreased, after the intervention (P<0.05). Moreover, plasma apelin and NOx levels were significantly increased in the training group after the intervention (P<0.05). Additionally, there was a correlation between the training effects of plasma apelin levels and carotidβ-stiffness (r = -0.508, P = 0.032) and plasma NOx levels (r = 0.494, P = 0.037). By contrast, none of these parameters changed significantly in the control group. These results suggest that the increased in plasma apelin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2014 Fujie et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
詳細を表示
資源タイプ
journal article
言語
English (英語)
eISSN
1932-6203
OPACで所蔵を検索
CiNiiで学外所蔵を検索
関連情報
DOI
https://doi.org/10.1371/journal.pone.0093545
ホームへ戻る