神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90004250
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2024-04-27
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90004250 (fulltext)
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メタデータID
90004250
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open access
出版タイプ
Version of Record
タイトル
Usefulness of the desaturation-distance ratio from the six-minute walk test for patients with COPD
著者
Fujimoto, Yukari ; Oki, Yutaro ; Kaneko, Masahiro ; Sakai, Hideki ; Misu, Shogo ; Yamaguchi, Takumi ; Mitani, Yuji ; Yasuda, Hisafumi ; Ishikawa, Akira
著者ID
A1318
著者名
Fujimoto, Yukari
藤本, 由香里
フジモト, ユカリ
所属機関名
地域連携推進室
著者名
Oki, Yutaro
著者名
Kaneko, Masahiro
著者名
Sakai, Hideki
著者名
Misu, Shogo
著者名
Yamaguchi, Takumi
著者名
Mitani, Yuji
著者ID
A0808
研究者ID
1000050403233
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=5582d1916fc5420c520e17560c007669
著者名
Yasuda, Hisafumi
安田, 尚史
ヤスダ, ヒサフミ
所属機関名
保健学研究科
著者ID
A1225
研究者ID
1000010295371
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=41a11f42708255cd520e17560c007669
著者名
Ishikawa, Akira
石川, 朗
イシカワ, アキラ
所属機関名
保健学研究科
収録物名
International Journal of Chronic Obstructive Pulmonary Disease
巻(号)
12
ページ
2669-2675
出版者
Dove Medical Press
刊行日
2017-09-06
公開日
2017-10-25
抄録
Purpose: A straightforward, noninvasive method is needed to assess emphysema and pulmonary hypertension (PH) in COPD patients. The desaturation-distance ratio (DDR) is an index derived from the distance traveled and level of desaturation during a six-minute walk test (6MWT); it has previously been shown to be associated with percentage of forced expiratory volume in the first second of expiration (%FEV1.0) and percentage of diffusion capacity of the lung for carbon monoxide (%DLCO). The aim of this study was to examine the associations between DDR and emphysema and PH. Patients and methods: We collected the following data for 74 stable COPD outpatients: lung function tests (%FEV1.0 and %DLCO), 6MWT distance and desaturation, and area of emphysema on computed tomography (percentage of low attenuation area). Enlargement of the pulmonary artery (PA) was assessed by the ratio of the diameter of the PA to that of the aorta (PA:A ratio) as an index of PH. DDR was calculated by the distance traveled and the degree of desaturation reached during a 6MWT. The relationships between study outcomes were assessed with Spearman's rank-correlation analysis. Receiver operating characteristic (ROC) curves were used to determine the threshold values with the optimum cutoff points for predicting severe or very severe airway obstruction, pulmonary diffusing capacity disorder, moderate or severe emphysema, and enlargement of the PA. Results: DDR correlated significantly with %FEV1.0, %DLCO, %LAA, and PA:A ratio. DDR showed high accuracy (area under the ROC curve >0.7) for predicting severe or very severe airway obstruction, pulmonary diffusing capacity disorder, moderate or severe emphysema, and enlargement of the PA. Conclusion: The results suggest that DDR is a good index of emphysema and PH in COPD patients. The 6MWT is widely used to assess COPD, and DDR could help with the early diagnosis of COPD.
カテゴリ
地域連携推進本部
保健学研究科
学術雑誌論文
権利
© 2017 Fujimoto et al.
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
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資源タイプ
journal article
言語
English (英語)
ISSN
1176-9106
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eISSN
1178-2005
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関連情報
DOI
https://doi.org/10.2147/COPD.S143477
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