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https://hdl.handle.net/20.500.14094/90004267
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2024-04-24
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90004267 (fulltext)
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メタデータID
90004267
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open access
出版タイプ
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タイトル
Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells
著者
Ogawa, Hiroyuki ; Koyanagi-Aoi, Michiyo ; Otani, Kyoko ; Zen, Yoh ; Maniwa, Yoshimasa ; Aoi, Takashi
著者ID
A1533
研究者ID
1000000727977
著者名
Ogawa, Hiroyuki
小川, 裕行
オガワ, ヒロユキ
所属機関名
医学部附属病院
著者名
Koyanagi-Aoi, Michiyo
著者名
Otani, Kyoko
著者名
Zen, Yoh
著者ID
A0782
研究者ID
1000050362778
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=5a0f3a6ba5a3f888520e17560c007669
著者名
Maniwa, Yoshimasa
眞庭, 謙昌
マニワ, ヨシマサ
所属機関名
医学研究科
著者ID
A0444
研究者ID
1000000546997
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fc332006706c5b9e520e17560c007669
著者名
Aoi, Takashi
青井, 貴之
アオイ, タカシ
所属機関名
科学技術イノベーション研究科
収録物名
Scientific Reports
巻(号)
7
ページ
12317-12317
出版者
Nature Publishing Group
刊行日
2017-09-26
公開日
2017-10-27
抄録
In the present study, we successfully generated lung cancer stem cell (CSC)-like cells by introducing a small set of transcription factors into a lung cancer cell line. In addition to properties that are conventionally referred to as CSC properties, the lung induced CSCs exhibited the ability to form lung cancer-like tissues in vitro with vascular cells and mesenchymal stem cells, which showed structures and immunohistological patterns that were similar to human lung cancer tissues. We named them “lung cancer organoids”. We found that interleukin-6 (IL-6), which was expressed in the lung induced CSCs, facilitates the formation of lung cancer organoids via the conversion of mesenchymal stem cells into alpha-smooth muscle actin (αSMA)-positive cells. Interestingly, the combination of anti-IL-6 antibody and cisplatin could destroy the lung cancer organoids, while cisplatin alone could not. Furthermore, IL-6 mRNA-positive cancer cells were found in clinical lung cancer samples. These results suggest that IL-6 could be a novel therapeutic target in lung cancer.
カテゴリ
医学研究科
医学部附属病院
科学技術イノベーション研究科
学術雑誌論文
権利
© The Author(s) 2017.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2045-2322
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関連情報
DOI
https://doi.org/10.1038/s41598-017-12017-y
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