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https://hdl.handle.net/20.500.14094/90004270
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2024-04-27
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90004270 (fulltext)
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90004270
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open access
出版タイプ
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タイトル
Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels
著者
Fujii, Yuki ; Maekawa, Shohei ; Morita, Mitsuhiro
著者名
Fujii, Yuki
著者ID
A0269
研究者ID
1000040173695
著者名
Maekawa, Shohei
前川, 昌平
マエカワ, ショウヘイ
所属機関名
理学研究科
著者ID
A0732
研究者ID
1000050297602
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=eb44d85269d72e68520e17560c007669
著者名
Morita, Mitsuhiro
森田, 光洋
モリタ, ミツヒロ
所属機関名
理学研究科
収録物名
Scientific Reports
巻(号)
7
ページ
13115-13115
出版者
Nature Publishing Group
刊行日
2017-10-13
公開日
2017-10-27
抄録
Wave-like propagation of [Ca2+](i) increases is a remarkable intercellular communication characteristic in astrocyte networks, intercalating neural circuits and vasculature. Mechanically-induced [Ca2+](i) increases and their subsequent propagation to neighboring astrocytes in culture is a classical model of astrocyte calcium wave and is known to be mediated by gap junction and extracellular ATP, but the role of each pathway remains unclear. Pharmacologic analysis of time-dependent distribution of [Ca2+](i)revealed three distinct [Ca2+](i) increases, the largest being in stimulated cells independent of extracellular Ca2+ and inositol 1,4,5-trisphosphate-induced Ca2+ release. In addition, persistent [Ca2+](i) increases were found to propagate rapidly via gap junctions in the proximal region, and transient [Ca2+](i) increases were found to propagate slowly via extracellular ATP in the distal region. Simultaneous imaging of astrocyte [Ca2+](i) and extracellular ATP, the latter of which was measured by an ATP sniffing cell, revealed that ATP was released within the proximal region by volume-regulated anion channel in a [Ca2+](i) independent manner. This detailed analysis of a classical model is the first to address the different contributions of two major pathways of calcium waves, gap junctions and extracellular ATP.
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理学研究科
学術雑誌論文
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© The Author(s) 2017.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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journal article
言語
English (英語)
eISSN
2045-2322
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DOI
https://doi.org/10.1038/s41598-017-13243-0
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