神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90004633
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2024-04-27
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90004633 (fulltext)
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メタデータID
90004633
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open access
出版タイプ
Version of Record
タイトル
Excessive scleral shrinkage, rather than choroidal thickening, is a major contributor to the development of hypotony maculopathy after trabeculectomy
著者
Sakamoto, Mari ; Matsumoto, Yoshiko ; Mori, Sotaro ; Ueda, Kaori ; Inoue, Yukako ; Kurimoto, Takuji ; Kanamori, Akiyasu ; Yamada, Yuko ; Nakamura, Makoto
著者名
Sakamoto, Mari
著者名
Matsumoto, Yoshiko
著者名
Mori, Sotaro
著者名
Ueda, Kaori
著者ID
A1503
著者名
Inoue, Yukako
井上, 結香子
イノウエ, ユカコ
所属機関名
医学研究科
著者ID
A1535
研究者ID
1000050388815
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=09106101bc83c492520e17560c007669
著者名
Kurimoto, Takuji
栗本, 拓治
クリモト, タクジ
所属機関名
医学部附属病院
著者ID
A1388
研究者ID
1000010444572
著者名
Kanamori, Akiyasu
金森, 章泰
カナモリ, アキヤス
所属機関名
医学部附属病院
著者ID
A1365
研究者ID
1000000359861
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=d9c758f40b2218da520e17560c007669
著者名
Yamada, Yuko
山田, 裕子
ヤマダ, ユウコ
所属機関名
医学研究科
著者ID
A0882
研究者ID
1000080273788
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=82142348522a81ad520e17560c007669
著者名
Nakamura, Makoto
中村, 誠
ナカムラ, マコト
所属機関名
医学研究科
収録物名
PLoS ONE
巻(号)
13(1)
ページ
e0191862-e0191862
出版者
Public Library of Science
刊行日
2018-01-26
公開日
2018-02-21
抄録
Purpose We previously reported that eyes with hypotony maculopathy (HM) after trabeculectomy (TLE) exhibited more reduction of axial length (AL) than those without HM, suggesting that inward collapse of the scleral wall may contribute to the development of HM after TLE. However, we did not evaluate change in choroidal thickness (CT), which could influence AL measures. We compared the magnitude and rate of AL and CT changes in eyes with and without HM by simultaneously measuring these parameters before and after TLE. Methods We enrolled 77 eyes of 77consecutive patients with glaucoma, who underwent TLE between March 2014 and March 2016. Intraocular pressure (IOP), central corneal thickness, keratometry, AL, and CT were measured pre- and postoperatively, up to 6 months. These biometrics were compared in eyes with and without HM. Results The 14 patients who developed HM were significantly younger than those who did not. The eyes with HM exhibited significantly reduced AL (2.8%) compared to those without HM (0.7%). There was no significant difference in CT change between the two groups. The rate of AL reduction was significantly correlated with age, postoperative IOP, and preoperative AL. Post-adjustment logistic regression analysis revealed that eyes with AL reduction rate ≥ 2% had 11.67 higher risk for developing HM (95% confidence interval, 1.28-106.6; P = 0.03). Conclusions AL reduction rates ≥ 2% were significantly associated with HM. Excessive reduction in AL, which was seen in eyes with HM, was not an artificial measure resulting from choroidal thickening but rather reflected reductions in the anterior-posterior diameter of the eyeball. Inward collapse of the scleral wall leads to redundancy of the chorioretinal tissue, contributing to the development of HM after TLE.
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2018 Sakamoto et al.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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資源タイプ
journal article
言語
English (英語)
eISSN
1932-6203
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関連情報
DOI
https://doi.org/10.1371/journal.pone.0191862
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