神戸大学附属図書館デジタルアーカイブ
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学内刊行物
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https://hdl.handle.net/20.500.14094/90004783
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2024-03-29
10:16 集計
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90004783 (fulltext)
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1.65 MB
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メタデータID
90004783
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Urinary WT1-positive cells as a non-invasive biomarker of crescent formation
著者
Fujita, T. ; Sofue, T. ; Moritoki, M. ; Nishijima, Y. ; Tokuhara, Y. ; Wakisaka, H. ; Kushida, Y. ; Haba, R. ; Ohsaki, H.
著者名
Fujita, T.
著者名
Sofue, T.
著者名
Moritoki, M.
著者名
Nishijima, Y.
著者名
Tokuhara, Y.
著者名
Wakisaka, H.
著者名
Kushida, Y.
著者名
Haba, R.
著者ID
A1356
研究者ID
1000080438291
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.c979710ad6b93847520e17560c007669.html
著者名
Ohsaki, H.
大﨑, 博之
オオサキ, ヒロユキ
所属機関名
保健学研究科
収録物名
Cytopathology
巻(号)
28(6)
ページ
524-530
出版者
Wiley
刊行日
2017-12
公開日
2019-01-01
抄録
Objective: The purpose of this study was to assess the relationship between urinary WT1-positive cells (podocytes and active parietal epithelial cells) and WT1-positive cells in renal biopsy to investigate whether urinary WT1-positive cells are useful for detection of crescent formation. Methods: Fifty-two patients with kidney disease were investigated (15 cases with crescentic lesions and 37 cases with non-crescentic lesions) for immunoenzyme staining using anti-WT1 antibody for urine cytology and renal biopsy. Numbers of WT1-positive cells in urine and renal biopsy were counted. Results: There was no correlation between urinary WT1-positive cells and WT1-positive cells in renal biopsy. However, the number of urinary WT1-positive cells in patients with crescentic lesions was significantly higher than in patients with non-crescentic lesions. In addition, the best cut-off value to detect patients with crescentic lesions using urinary was 5 cells/10-mL (area under the concentration‐time curve=0.735). Conclusions: The results of our study suggest urinary WT1-positive cells can be used to detect patients with crescent formation using 5 cells/10-mL cutoff value. WT1-positive glomerular podocytes and parietal epithelial cells may be shed into urine in active glomerular disease. This study, investigating the relationship between WT1-positive cells in urine and in the renal biopsy found no correlation; however, the results do suggest that, using a cutoff value of 5 cells/10 mL, WT1 positive urinary cells can be used to detect patients with crescent formation.
キーワード
crescent formation
immunocytochemistry
liquid-based cytology
urine cytology
WT1
カテゴリ
保健学研究科
学術雑誌論文
権利
© 2017 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: [Cytopathology, 28(6):524-530, 2017], which has been published in final form at http://dx.doi.org/10.1111/cyt.12460. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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資源タイプ
journal article
言語
English (英語)
ISSN
0956-5507
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eISSN
1365-2303
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関連情報
DOI
https://doi.org/10.1111/cyt.12460
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