神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90004859
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2024-04-27
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90004859 (fulltext)
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90004859
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open access
出版タイプ
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タイトル
Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report
著者
Hirashio, Shuma ; Satoh, Ayaka ; Arima, Takahiro ; Mandai, Kouichi ; Awaya, Tadasuke ; Oshima, Kumi ; Hara, Shigeo ; Masaki, Takao
著者名
Hirashio, Shuma
著者名
Satoh, Ayaka
著者名
Arima, Takahiro
著者名
Mandai, Kouichi
著者名
Awaya, Tadasuke
著者名
Oshima, Kumi
著者ID
A1429
研究者ID
1000010590648
著者名
Hara, Shigeo
原, 重雄
ハラ, シゲオ
所属機関名
医学部附属病院
著者名
Masaki, Takao
収録物名
BMC Nephrology
巻(号)
19
ページ
108-108
出版者
BioMed Central
刊行日
2018-05-03
公開日
2018-05-16
抄録
Background: Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway. In most cases, C3 glomerulopathy manifests pathologically with membranoproliferative glomerulonephritis-like features. An association between C3 glomerulopathy and monoclonal gammopathy was recently reported in several cases, raising the possibility that C3 glomerulopathy is the underlying pathological process in monoclonal gammopathy of renal significance. Case presentation: We herein report a case of monoclonal gammopathy-induced DDD that improved histologically and clinically with chemotherapy including bortezomib. Our case is the first in which treatment response can be linked to the histological response. Potential pathological insights are also discussed. Conclusions: Rapid and efficient chemotherapy has the potential to limit renal damage in monoclonal gammopathy-associated DDD.
キーワード
C3 glomerulopathy
Complement
Dense deposit disease
Monoclonal gammopathy of renal significance
Monoclonal gammopathy of undetermined significance
カテゴリ
医学部附属病院
学術雑誌論文
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© The Author(s). 2018
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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journal article
言語
English (英語)
eISSN
1471-2369
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関連情報
DOI
https://doi.org/10.1186/s12882-018-0905-6
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