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https://hdl.handle.net/20.500.14094/90004920
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2024-04-20
22:47 集計
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90004920 (fulltext)
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メタデータID
90004920
アクセス権
open access
出版タイプ
Version of Record
タイトル
Immediate elimination of injured white matter tissue achieves a rapid axonal growth across the severed spinal cord in adult rats
著者
Nishio, Takeshi ; Fujiwara, Hiroshi ; Kanno, Isaku
著者名
Nishio, Takeshi
著者名
Fujiwara, Hiroshi
著者ID
A0414
研究者ID
1000070346039
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a56f282d3260eea8520e17560c007669
著者名
Kanno, Isaku
神野, 伊策
カンノ, イサク
所属機関名
工学研究科
収録物名
Neuroscience Research
巻(号)
131
ページ
19-29
出版者
Elsevier
刊行日
2018-06
公開日
2018-06-06
抄録
In general, axonal regeneration is very limited after transection of adult rat spinal cord. We previously demonstrated that regenerative axons reached the lesion site within 6 h of sharp transection with a thin scalpel. However, they failed to grow across the lesion site, where injured axon fragments (axon-glial complex, AGC) were accumulated. Considering a possible role of these axon fragments as physicochemical barriers, we examined the effects of prompt elimination of the barriers on axonal growth beyond the lesion site. In this study, we made additional oblique section immediately after the primary transection and surgically eliminated the AGC (debridement). Under this treatment, regenerative axons successfully traversed the lesion site within 4h of surgery. To exclude axonal sparing, we further inserted a pored sheet into the debrided lesion and observed the presence of fascicles of unmyelinated axons traversing the sheet through the pores by electron microscopy, indicating bona fide regeneration. These results suggest that the sequential trial of reduction and early elimination of the physicochemical barriers is one of the effective approaches to induce spontaneous and rapid regeneration beyond the lesion site.
キーワード
Regenerative pioneering axon
Regenerative follower axon
Axon-glial complex
Debridement
Fascicle formation
Axon segments (fragments)
カテゴリ
工学研究科
学術雑誌論文
権利
© 2017 The Authors. Published by Elsevier Ireland Ltd.
This is an open access article under the CC BY-NC-ND license.
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資源タイプ
journal article
言語
English (英語)
ISSN
0168-0102
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eISSN
1872-8111
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関連情報
DOI
https://doi.org/10.1016/j.neures.2017.10.011
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