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https://hdl.handle.net/20.500.14094/90004990
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2024-04-20
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90004990 (fulltext)
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メタデータID
90004990
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open access
出版タイプ
Version of Record
タイトル
Association of advanced glycation end products in Dupuytren disease
著者
Takase, Fumiaki ; Mifune, Yutaka ; Inui, Atsuyuki ; Ueda, Yasuhiro ; Kataoka, Takeshi ; Kokubu, Takeshi ; Kuroda, Ryosuke
著者名
Takase, Fumiaki
著者ID
A0826
研究者ID
1000080608464
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a355369a8c047f2e520e17560c007669
著者名
Mifune, Yutaka
美舩, 泰
ミフネ, ユタカ
所属機関名
医学部附属病院
著者ID
A2076
研究者ID
1000070457092
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cf677d34bcd544b8520e17560c007669
著者名
Inui, Atsuyuki
乾, 淳幸
イヌイ, アツユキ
所属機関名
医学部附属病院
著者名
Ueda, Yasuhiro
著者名
Kataoka, Takeshi
著者ID
A1389
研究者ID
1000040403266
著者名
Kokubu, Takeshi
国分, 毅
コクブ, タケシ
所属機関名
医学部附属病院
著者ID
A0783
研究者ID
1000080379362
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f51cbfc82378ae63520e17560c007669
著者名
Kuroda, Ryosuke
黒田, 良祐
クロダ, リョウスケ
所属機関名
医学研究科
収録物名
Journal of Orthopaedic Surgery and Research
巻(号)
13
ページ
143-143
出版者
BioMed Central
刊行日
2018-06-07
公開日
2018-07-05
抄録
Background: Advanced glycation end products are associated with aging, hyperglycemia, and oxidative stress. Accumulation of advanced glycation end products can cause various pathological conditions; however, the association of Dupuytren's disease with advanced glycation end products has not been demonstrated yet. The aim of this study is to investigate the association of Dupuytren's disease with advanced glycation end products. Methods: Normal palmar fascia from five patients with carpal tunnel syndrome (control group) and Dupuytren's cords from five patients (Dupuytren's disease group) were harvested. The tissues were stained using an anti-advanced glycation end products antibody, anti-receptor for advanced glycation end products antibody, and an anti-reactive oxygen species modulator 1 antibody. The expression of nicotinamide adenine dinucleotide phosphate oxidase-1 and nicotinamide adenine dinucleotide phosphate oxidase-4 genes was also assessed using real-time PCR. For in vitro analysis, the cells harvested from the control and Dupuytren's disease groups were used. After 3 days of exposure to four types of media (control group, control + advanced glycation end products group, Dupuytren's disease group, Dupuytren's disease + advanced glycation end products group), superoxide detection reagent was detected using a total reactive oxygen species/superoxide detection kit. Results: Immunostaining of the palmar fasciae of the Dupuytren's disease group showed higher expressions of advanced glycation end products and receptor for advanced glycation end products than that in the control group. The expression of nicotinamide adenine dinucleotide phosphate oxidase oxidase-1 and nicotinamide adenine dinucleotide phosphate oxidase-4 as well as reactive oxygen species modulator 1, an oxidatively damaged protein, was also higher in the Dupuytren's disease group than in the control group. In an in vitro cell culture, the addition of advanced glycation end products to the Dupuytren's disease-derived cells produced more superoxide free radicals. Conclusions: These data suggest that the advanced glycation end products receptor for advanced glycation end products interaction produced free radicals via nicotinamide adenine dinucleotide phosphate oxidase activation in Dupuytren's disease patients. Further studies are required to confirm these results.
キーワード
Dupuytren's disease
Advanced glycation end products (AGEs)
Oxidation
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© The Author(s). 2018.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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資源タイプ
journal article
言語
English (英語)
eISSN
1749-799X
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関連情報
DOI
https://doi.org/10.1186/s13018-018-0848-4
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