神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90005013
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2024-04-23
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90005013 (fulltext)
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90005013
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open access
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タイトル
A case of immunotactoid glomerulopathy with false-negative IgG staining
著者
Hirashio, Shuma ; Arima, Takahiro ; Satoh, Ayaka ; Mandai, Kouichi ; Hara, Shigeo ; Masaki, Takao
著者名
Hirashio, Shuma
著者名
Arima, Takahiro
著者名
Satoh, Ayaka
著者名
Mandai, Kouichi
著者ID
A1429
研究者ID
1000010590648
著者名
Hara, Shigeo
原, 重雄
ハラ, シゲオ
所属機関名
医学部附属病院
著者名
Masaki, Takao
収録物名
BMC Nephrology
巻(号)
19
ページ
143-143
出版者
BioMed Central
刊行日
2018-06-15
公開日
2018-07-11
抄録
Background: Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative giomerular diseases. The characteristic tubular structure on electron microscopy is essential for a definitive diagnosis, and the diameter of the structure has been traditionally used for differentiating between ITG and other types of glomerulonephritis with organized deposits. in recent years, the disease concept of monoclonal gammopathy of renal significance, which is associated with M protein produced by plasma cell tumors, has been proposed. Case presentation: This was a peculiar case of ITG with underlying monoclonal gammopathy in which IgG showed a false-negative result with immunofluorescence using frozen sections. Additional examinations using a different clone of the anti-IgG antibody revealed typical IgG staining. C4d was strongly positive, consistent with immune complex type glomerulonephritis. Conclusions: This case highlights unusual features of ITG, and provides a practical hint to avoid a diagnostic pitfall.
キーワード
Immunotactoid glomerulopathy
False-negative
Monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of renal significance
カテゴリ
医学部附属病院
学術雑誌論文
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© The Author(s). 2018.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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資源タイプ
journal article
言語
English (英語)
eISSN
1471-2369
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DOI
https://doi.org/10.1186/s12882-018-0931-4
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