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https://hdl.handle.net/20.500.14094/90005058
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2024-04-24
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90005058 (fulltext)
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メタデータID
90005058
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open access
出版タイプ
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タイトル
Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation
著者
Zhang, Boyang ; Nakata, Masanori ; Nakae, Jun ; Ogawa, Wataru ; Yada, Toshihiko
著者名
Zhang, Boyang
著者名
Nakata, Masanori
著者名
Nakae, Jun
著者ID
A1358
研究者ID
1000040294219
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=38228987a3a438c8520e17560c007669
著者名
Ogawa, Wataru
小川, 渉
オガワ, ワタル
所属機関名
医学研究科
著者名
Yada, Toshihiko
収録物名
Scientific Reports
巻(号)
8
ページ
10415-10415
出版者
Nature Publishing Group
刊行日
2018-07-10
公開日
2018-07-24
抄録
Oxytocin neurons in the paraventricular nucleus (PVN) of hypothalamus regulate energy metabolism and reproduction. Plasma oxytocin concentration is reduced in obese subjects with insulin resistance. These findings prompted us to hypothesize that insulin serves to promote oxytocin release. This study examined whether insulin activates oxytocin neurons in the PVN, and explored the underlying signaling. We generated the mice deficient of 3-phosphoinositide-dependent protein kinase-1 (PDK1), a major signaling molecule particularly for insulin, specifically in oxytocin neurons (Oxy Pdk1 KO). Insulin increased cytosolic calcium concentration ([Ca2+](i)) in oxytocin neurons with larger (≧25 μm) and smaller (<25 μm) diameters isolated from PVN in C57BL/6 mice. In PDK1 Oxy Pdk1 KO mice, in contrast, this effect of insulin to increase [Ca2+](i) was markedly diminished in the larger-sized oxytocin neurons, while it was intact in the smaller-sized oxytocin neurons. Furthermore, intracerebroventricular insulin administration induced oxytocin release into plasma in Oxy Cre but not Oxy Pdk1 KO mice. These results demonstrate that insulin PDK1-dependently preferentially activates PVN magnocellular oxytocin neurons to release oxytocin into circulation, possibly serving as a mechanism for the interaction between metabolism and perinatal functions.
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医学研究科
学術雑誌論文
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© The Author(s) 2018.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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journal article
言語
English (英語)
eISSN
2045-2322
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DOI
https://doi.org/10.1038/s41598-018-28816-w
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