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https://hdl.handle.net/20.500.14094/90005085
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2024-04-20
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90005085 (fulltext)
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メタデータID
90005085
アクセス権
open access
出版タイプ
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タイトル
Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
著者
Kishimoto, Keishi ; Tamura, Masaru ; Nishita, Michiru ; Minami, Yasuhiro ; Yamaoka, Akira ; Abe, Takaya ; Shigeta, Mayo ; Morimoto, Mitsuru
著者名
Kishimoto, Keishi
著者名
Tamura, Masaru
著者ID
A0785
研究者ID
1000030379359
著者名
Nishita, Michiru
西田, 満
ニシタ, ミチル
所属機関名
医学研究科
著者ID
A0499
研究者ID
1000070229772
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=9f86495b89d5a974520e17560c007669
著者名
Minami, Yasuhiro
南, 康博
ミナミ, ヤスヒロ
所属機関名
医学研究科
著者名
Yamaoka, Akira
著者名
Abe, Takaya
著者名
Shigeta, Mayo
著者名
Morimoto, Mitsuru
収録物名
Nature Communications
巻(号)
9
ページ
2816-2816
出版者
Nature Publishing Group
刊行日
2018-07-19
公開日
2018-08-02
抄録
Tube morphogenesis is essential for internal-organ development, yet the mechanisms regulating tube shape remain unknown. Here, we show that different mechanisms regulate the length and diameter of the murine trachea. First, we found that trachea development progresses via sequential elongation and expansion processes. This starts with a synchronized radial polarization of smooth muscle (SM) progenitor cells with inward Golgi-apparatus displacement regulates tube elongation, controlled by mesenchymal Wnt5a-Ror2 signaling. This radial polarization directs SM progenitor cell migration toward the epithelium, and the resulting subepithelial morphogenesis supports tube elongation to the anteroposterior axis. This radial polarization also regulates esophageal elongation. Subsequently, cartilage development helps expand the tube diameter, which drives epithelial-cell reshaping to determine the optimal lumen shape for efficient respiration. These findings suggest a strategy in which straight-organ tubulogenesis is driven by subepithelial cell polarization and ring cartilage development.
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医学研究科
学術雑誌論文
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© The Author(s) 2018.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2041-1723
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関連情報
DOI
https://doi.org/10.1038/s41467-018-05189-2
URI
http://www.kobe-u.ac.jp/research_at_kobe/NEWS/news/2018_07_26_01.html
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