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https://hdl.handle.net/20.500.14094/90005300
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2024-04-20
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90005300 (fulltext)
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90005300
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open access
出版タイプ
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タイトル
Muscle Androgen Receptor Content but Not Systemic Hormones Is Associated With Resistance Training-Induced Skeletal Muscle Hypertrophy in Healthy, Young Men
著者
Morton, Robert W. ; Sato, Koji ; Gallaugher, Michael P. B. ; Oikawal, Sara Y. ; McNicholas, Paul D. ; Fujita, Satoshi ; Phillips, Stuart M.
著者名
Morton, Robert W.
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Gallaugher, Michael P. B.
著者名
Oikawal, Sara Y.
著者名
McNicholas, Paul D.
著者名
Fujita, Satoshi
著者名
Phillips, Stuart M.
収録物名
Frontiers in Physiology
巻(号)
9
ページ
1373-1373
出版者
Frontiers Media
刊行日
2018-10-09
公開日
2018-10-24
抄録
The factors that underpin heterogeneity in muscle hypertrophy following resistance exercise training (RET) remain largely unknown. We examined circulating hormones, intramuscular hormones, and intramuscular hormone-related variables in resistance-trained men before and after 12 weeks of RET. Backward elimination and principal component regression evaluated the statistical significance of proposed circulating anabolic hormones (e.g., testosterone, free testosterone, dehydroepiandrosterone, dihydrotestosterone, insulin-like growth factor-1, free insulin-like growth factor-1, luteinizing hormone, and growth hormone) and RET-induced changes in muscle mass (n = 49). Immunoblots and immunoassays were used to evaluate intramuscular free testosterone levels, dihydrotestosterone levels, 5α-reductase expression, and androgen receptor content in the highest- (HIR; n = 10) and lowest- (LOR; n = 10) responders to the 12 weeks of RET. No hormone measured before exercise, after exercise, pre-intervention, or post-intervention was consistently significant or consistently selected in the final model for the change in: type 1 cross sectional area (CSA), type 2 CSA, or fat- and bone-free mass (LBM). Principal component analysis did not result in large dimension reduction and principal component regression was no more effective than unadjusted regression analyses. No hormone measured in the blood or muscle was different between HIR and LOR. The steroidogenic enzyme 5α-reductase increased following RET in the HIR (P < 0.01) but not the LOR (P = 0.32). Androgen receptor content was unchanged with RET but was higher at all times in HIR. Unlike intramuscular free testosterone, dihydrotestosterone, or 5α-reductase, there was a linear relationship between androgen receptor content and change in LBM (P < 0.01), type 1 CSA (P < 0.05), and type 2 CSA (P < 0.01) both pre- and post-intervention. These results indicate that intramuscular androgen receptor content, but neither circulating nor intramuscular hormones (or the enzymes regulating their intramuscular production), influence skeletal muscle hypertrophy following RET in previously trained young men.
キーワード
resistance exercise
testosterone
intramuscular
androgen receptor
hypertrophy
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2018 Morton, Sato, Gallaugher, Oikawa, McNicholas, Fujita and Phillips.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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資源タイプ
journal article
言語
English (英語)
eISSN
1664-042X
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関連情報
DOI
https://doi.org/10.3389/fphys.2018.01373
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