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https://hdl.handle.net/20.500.14094/90005413
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2024-04-27
08:22 集計
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90005413 (fulltext)
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メタデータID
90005413
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Delayed Socket Healing After Dental Extraction in Patients Undergoing Myelosuppressive Chemotherapy for Hematological Malignancy: Incidence and Risk Factors
著者
Akashi, Masaya ; Kishimoto, Megumi ; Kusumoto, Junya ; Yakushijin, Kimikazu ; Matsuoka, Hiroshi ; Komori, Takahide
著者ID
A1492
研究者ID
1000040597168
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b7649a2950dc725a520e17560c007669
著者名
Akashi, Masaya
明石, 昌也
アカシ, マサヤ
所属機関名
医学研究科
著者名
Kishimoto, Megumi
著者名
Kusumoto, Junya
著者ID
A0811
研究者ID
1000030403281
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cfd25a3142500cea520e17560c007669
著者名
Yakushijin, Kimikazu
藥師神, 公和
ヤクシジン, キミカズ
所属機関名
医学部附属病院
著者ID
A0809
研究者ID
1000050418878
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=e7e2351a11fdef95520e17560c007669
著者名
Matsuoka, Hiroshi
松岡, 広
マツオカ, ヒロシ
所属機関名
医学研究科
著者ID
A0121
研究者ID
1000050251294
著者名
Komori, Takahide
古森, 孝英
コモリ, タカヒデ
所属機関名
医学研究科
収録物名
Journal of Oral and Maxillofacial Surgery
巻(号)
76(10)
ページ
2057-2065
出版者
Elsevier
刊行日
2018-10
公開日
2019-11-01
抄録
Purpose: The purpose of this study was to measure the frequency and identify factors associated with delayed socket healing after dental extraction in patients undergoing myelosuppressive chemotherapy for hematologic malignancy. Materials and Methods: This prospective cohort study focused on delayed healing after extraction in patients with hematologic malignancy. Sockets with delayed healing were defined as those with intense pain and bone exposure 1 week postoperatively. Patients with and without delayed socket healing were compared using the Fisher exact test and Mann-Whitney U test with some variables. Receiver operating characteristics curve analysis was conducted to define cutoff values for delayed healing. Results: One hundred ninety-four dental extractions in 93 patients (median age, 64 yr; range, 20 to 85 yr) were analyzed. The incidence of delayed socket healing was 7.5% (7 of 93 patients). There was no postoperative bleeding. Older age, type of hematologic malignancy (acute leukemia), shorter time from dental extraction to initiation of chemotherapy, low platelet count or hemoglobin level, requirement for red blood cell concentrate or platelet transfusion, and use of an absorbable hemostatic agent were statistically associated with the occurrence of delayed socket healing. Platelet and hemoglobin cutoffs were 4.6 x 10(4)/μL and 7.7 g/dL, respectively. Conclusions: Although dental extraction can be safely performed in patients undergoing myelosuppressive chemotherapy for hematologic malignancy, oral surgeons should understand the potential risk for delayed socket healing. When considering dental extraction, patients with hematologic malignancy and low hemoglobin or platelet levels should be informed about the possibility of delayed socket healing.
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2018 American Association of Oral and Maxillofacial Surgeons.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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資源タイプ
journal article
言語
English (英語)
ISSN
0278-2391
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eISSN
1531-5053
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NCID
AA10628202
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関連情報
DOI
https://doi.org/10.1016/j.joms.2018.05.023
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