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https://hdl.handle.net/20.500.14094/90005450
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2024-04-20
13:07 集計
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90005450 (fulltext)
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メタデータID
90005450
アクセス権
open access
出版タイプ
Version of Record
タイトル
Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters
著者
Kaihatsu, Kunihiro ; Yamabe, Miyuki ; Ebara, Yasuhito
著者ID
A2281
研究者ID
1000070419464
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=25e2524a29d1986d520e17560c007669
著者名
Kaihatsu, Kunihiro
開發, 邦宏
カイハツ, クニヒロ
所属機関名
人間発達環境学研究科
著者名
Yamabe, Miyuki
著者ID
A0324
研究者ID
1000040251657
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=784717836b240063520e17560c007669
著者名
Ebara, Yasuhito
江原, 靖人
エバラ, ヤスヒト
所属機関名
人間発達環境学研究科
収録物名
Molecules
巻(号)
23(10)
ページ
2475-2475
出版者
MDPI
刊行日
2018-09-27
公開日
2018-12-13
抄録
Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modifications of EGCG in terms of enhanced antiviral efficacy. This paper discusses which steps of virus infection EGCG interferes with, citing previous reports. EGCG appears most likely to inhibits the early stage of infections, such as attachment, entry, and membrane fusion, by interfering with viral membrane proteins. According to the relationships between structure and antiviral activity of catechin derivatives, the 3-galloyl and 5'-OH group of catechin derivatives appear critical to antiviral activities. Enhancing the binding affinity of EGCG to virus particles would thus be important to increase virucidal activity. We propose a newly developed EGCG-fatty acid derivative in which the fatty acid on the phenolic hydroxyl group would be expected to increase viral and cellular membrane permeability. EGCG-fatty acid monoesters showed improved antiviral activities against different types of viruses, probably due to their increased affinity for virus and cellular membranes. Our study promotes the application of EGCG-fatty acid derivatives for the prevention and treatment of viral infections.
キーワード
catechin
epigallocatechin-3-O-gallate
virus inhibition
attachment
entry
fusion
replication
budding
fatty acid derivative
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
eISSN
1420-3049
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関連情報
DOI
https://doi.org/10.3390/molecules23102475
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