神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90005507
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2024-04-18
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90005507 (fulltext)
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2.39 MB
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メタデータID
90005507
アクセス権
open access
出版タイプ
Version of Record
タイトル
Microglia Enhance Synapse Activity to Promote Local Network Synchronization
著者
Akiyoshi, Ryohei ; Wake, Hiroaki ; Kato, Daisuke ; Horiuchi, Hiroshi ; Ono, Riho ; Ikegami, Ako ; Haruwaka, Koichiro ; Omori, Toshiaki ; Tachibana, Yoshihisa ; Moorhouse, Andrew J. ; Nabekura, Junichi
著者名
Akiyoshi, Ryohei
著者ID
A0029
研究者ID
1000090455220
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=0dd6999dcebbbf8b520e17560c007669
著者名
Wake, Hiroaki
和氣, 弘明
ワケ, ヒロアキ
所属機関名
医学研究科
著者名
Kato, Daisuke
著者名
Horiuchi, Hiroshi
著者名
Ono, Riho
著者名
Ikegami, Ako
著者名
Haruwaka, Koichiro
著者ID
A0310
研究者ID
1000010391898
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8ccde8ac5b4f0a11520e17560c007669
著者名
Omori, Toshiaki
大森, 敏明
オオモリ, トシアキ
所属機関名
工学研究科
著者ID
A1943
研究者ID
1000050373197
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=5e6e4f83c9433d28520e17560c007669
著者名
Tachibana, Yoshihisa
橘, 吉寿
タチバナ, ヨシヒサ
所属機関名
医学研究科
著者名
Moorhouse, Andrew J.
著者名
Nabekura, Junichi
収録物名
eNeuro
巻(号)
5(5)
ページ
e0088-18.2018
出版者
Society for Neuroscience
刊行日
2018-09
公開日
2019-01-16
抄録
Microglia are highly motile immunoreactive cells that play integral roles in the response to brain infection and damage, and in the progression of various neurological diseases. During development, microglia also help sculpt neural circuits, via both promoting synapse formation and by targeting specific synapses for elimination and phagocytosis. Microglia are also active surveyors of neural circuits in the mature, healthy brain, although the functional consequences of such microglia-neuron contacts under these conditions is unclear. Using in vivo imaging of neurons and microglia in awake mice, we report here the functional consequences of microglia-synapse contacts. Direct contact between a microglial process and a single synapse results in a specific increase in the activity of that contacted synapse, and a corresponding increase in back-propagating action potentials along the parent dendrite. This increase in activity is not seen for microglia-synapse contacts when microglia are activated by chronic lipopolysaccharide (LPS) treatment. To probe how this microglia-synapse contact affects neural circuits, we imaged across larger populations of motor cortical neurons. When microglia were again activated by LPS (or partially ablated), there was a decrease in the extent to which neuronal activity was synchronized. Together, our results demonstrate that interactions between physiological or resting microglia and synapses in the mature, healthy brain leads to an increase in neuronal activity and thereby helps to synchronize local populations of neurons. Our novel findings provide a plausible physical basis for understanding how alterations in immune status may impact on neural circuit plasticity and on cognitive behaviors such as learning.
キーワード
calcium imaging
in vivo
microglia
synapse
two photon
カテゴリ
医学研究科
工学研究科
学術雑誌論文
権利
© 2018 Akiyoshi et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
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資源タイプ
journal article
言語
English (英語)
eISSN
2373-2822
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関連情報
DOI
https://doi.org/10.1523/ENEURO.0088-18.2018
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