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https://hdl.handle.net/20.500.14094/90005567
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2024-03-28
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90005567 (fulltext)
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メタデータID
90005567
アクセス権
open access
出版タイプ
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タイトル
Respiratory mechanics and cerebral blood flow during heat-induced hyperventilation and its voluntary suppression in passively heated humans
著者
Tsuji, Bun ; Hoshi, Yuta ; Honda, Yasushi ; Fujii, Naoto ; Sasaki, Yosuke ; Cheung, Stephen S. ; Kondo, Narihiko ; Nishiyasu, Takeshi
著者名
Tsuji, Bun
著者名
Hoshi, Yuta
著者名
Honda, Yasushi
著者名
Fujii, Naoto
著者名
Sasaki, Yosuke
著者名
Cheung, Stephen S.
著者ID
A0541
研究者ID
1000070215458
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.f271f58d8a182b6d520e17560c007669.html
著者名
Kondo, Narihiko
近藤, 徳彦
コンドウ, ナリヒコ
所属機関名
人間発達環境学研究科
著者名
Nishiyasu, Takeshi
収録物名
Physiological Reports
巻(号)
7(1)
ページ
e13967-e13967
出版者
Wiley
刊行日
2019-01
公開日
2019-02-06
抄録
We investigated whether heat-induced hyperventilation can be voluntarily prevented, and, if so, how this modulates respiratory mechanics and cerebral blood flow in resting heated humans. In two separate trials, 10 healthy men were passively heated using lower body hot-water immersion and a water-perfused garment covering their upper body (both 41°C) until esophageal temperature (T-es) reached 39°C or volitional termination. In each trial, participants breathed normally (normal-breathing) or voluntarily controlled minute ventilation (V-E) at a level equivalent to that observed after 5 min of heating (controlled-breathing). Respiratory gases, middle cerebral artery blood velocity (MCAV), work of breathing, and end-expiratory and inspiratory lung volumes were measured. During normal-breathing, V-E increased as T-es rose above 38.0 ± 0.3°C, whereas controlled-breathing diminished the increase in V-E (V-E at T-es = 38.6°C: 25.6 ± 5.9 and 11.9 ± 1.3 L min(-1) during normal- and controlled-breathing, respectively, P < 0.001). During normal-breathing, end-tidal CO2 pressure and MCAV decreased with rising T-es, but controlled-breathing diminished these reductions (at T-es = 38.6°C, 24.7 ± 5.0 vs. 39.5 ± 2.8 mmHg; 44.9 ± 5.9 vs. 60.2 ± 6.3 cm sec(-1), both P < 0.001). The work of breathing correlated positively with changes in V-E (P < 0.001) and was lower during controlled- than normal-breathing (16.1 ± 12.6 and 59.4 ± 49.5 J min(-1), respectively, at heating termination, P = 0.013). End-expiratory and inspiratory lung volumes did not differ between trials (P = 0.25 and 0.71, respectively). These results suggest that during passive heating at rest, heat-induced hyperventilation increases the work of breathing without affecting end-expiratory lung volume, and that voluntary control of breathing can nearly abolish this hyperventilation, thereby diminishing hypocapnia, cerebral hypoperfusion, and increased work of breathing.
キーワード
Cerebral blood flow
hyperpnea
hyperthermia
voluntary control of breathing
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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資源タイプ
journal article
言語
English (英語)
eISSN
2051-817X
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関連情報
DOI
https://doi.org/10.14814/phy2.13967
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