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https://hdl.handle.net/20.500.14094/90005590
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2024-04-23
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90005590 (fulltext)
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メタデータID
90005590
アクセス権
open access
出版タイプ
Version of Record
タイトル
Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma
著者
Yamakawa, Nobuhiro ; Kirita, Tadaaki ; Umeda, Masahiro ; Yanamoto, Souichi ; Ota, Yoshihide ; Otsuru, Mitsunobu ; Okura, Masaya ; Kurita, Hiroshi ; Yamada, Shin-ichi ; Hasegawa, Takumi ; Aikawa, Tomonao ; Komori, Takahide ; Ueda, Michihiro ; Japan Oral Oncology Group (JOOG)
著者名
Yamakawa, Nobuhiro
著者名
Kirita, Tadaaki
著者名
Umeda, Masahiro
著者名
Yanamoto, Souichi
著者名
Ota, Yoshihide
著者名
Otsuru, Mitsunobu
著者名
Okura, Masaya
著者名
Kurita, Hiroshi
著者名
Yamada, Shin-ichi
著者ID
A1489
研究者ID
1000050546497
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=322ffbb7f3848e30520e17560c007669
著者名
Hasegawa, Takumi
長谷川, 巧実
ハセガワ, タクミ
所属機関名
医学部附属病院
著者名
Aikawa, Tomonao
著者ID
A0121
研究者ID
1000050251294
著者名
Komori, Takahide
古森, 孝英
コモリ, タカヒデ
所属機関名
医学研究科
著者名
Ueda, Michihiro
著者名
Japan Oral Oncology Group (JOOG)
収録物名
Journal of Surgical Oncology
巻(号)
119(3)
ページ
370-378
出版者
Wiley
刊行日
2019-03-01
公開日
2019-02-13
抄録
Background and Objectives Some patients with early-stage oral cancer have a poor prognosis owing to the delayed neck metastasis (DNM). Tumor budding is reportedly a promising prognostic marker in many cancers. Moreover, the tissue surrounding a tumor is also considered to play a prognostic role. In this study, we evaluated whether tumor budding and adjacent tissue at the invasive front can be potential novel predictors of DNM in early tongue cancer. Methods In total, 337 patients with early-stage tongue squamous cell carcinoma were retrospectively reviewed. The patient characteristics and histopathological factors were evaluated for association with DNM. DNM rates were calculated; items which were significant in the univariate analysis were used as explanatory variables, and independent factors for DNM were identified by the multivariate analysis. Results The univariate analysis identified T classification, depth of invasion, tumor budding, vascular invasion, and adjacent tissue at the invasive front as significant predictors of DNM; the multivariate analysis using these factors revealed all the above variables except vascular invasion, which are independent predictors of DNM. Conclusion In addition to conventional predictors, high grade tumor budding and adjacent tissue at the invasive front can serve as useful predictors of DNM in early tongue cancer.
キーワード
metachronous neck metastasis
prognostic indicator
small cancer-cell clusters
tongue cancer
tumor-adjacent tissue
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2018 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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資源タイプ
journal article
言語
English (英語)
ISSN
0022-4790
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eISSN
1096-9098
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関連情報
DOI
https://doi.org/10.1002/jso.25334
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