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https://hdl.handle.net/20.500.14094/90005646
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2024-04-25
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90005646 (fulltext)
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メタデータID
90005646
アクセス権
open access
出版タイプ
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タイトル
Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects
著者
Ohashi, Kaoru ; Fujii, Masashi ; Uda, Shinsuke ; Kubota, Hiroyuki ; Komada, Hisako ; Sakaguchi, Kazuhiko ; Ogawa, Wataru ; Kuroda, Shinya
著者名
Ohashi, Kaoru
著者名
Fujii, Masashi
著者名
Uda, Shinsuke
著者名
Kubota, Hiroyuki
著者名
Komada, Hisako
著者ID
A1387
研究者ID
1000020444573
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cc9462ee69a7a403520e17560c007669
著者名
Sakaguchi, Kazuhiko
坂口, 一彦
サカグチ, カズヒコ
所属機関名
医学研究科
著者ID
A1358
研究者ID
1000040294219
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=38228987a3a438c8520e17560c007669
著者名
Ogawa, Wataru
小川, 渉
オガワ, ワタル
所属機関名
医学研究科
著者名
Kuroda, Shinya
収録物名
npj Systems Biology and Applications
巻(号)
4
ページ
14-14
出版者
Nature Research
刊行日
2018-03-14
公開日
2019-03-08
抄録
Insulin plays a central role in glucose homeostasis, and impairment of insulin action causes glucose intolerance and leads to type 2 diabetes mellitus (T2DM). A decrease in the transient peak and sustained increase of circulating insulin following an infusion of glucose accompany T2DM pathogenesis. However, the mechanism underlying this abnormal temporal pattern of circulating insulin concentration remains unknown. Here we show that changes in opposite direction of hepatic and peripheral insulin clearance characterize this abnormal temporal pattern of circulating insulin concentration observed in T2DM. We developed a mathematical model using a hyperglycemic and hyperinsulinemic-euglycemic clamp in 111 subjects, including healthy normoglycemic and diabetic subjects. The hepatic and peripheral insulin clearance significantly increase and decrease, respectively, from healthy to borderline type and T2DM. The increased hepatic insulin clearance reduces the amplitude of circulating insulin concentration, whereas the decreased peripheral insulin clearance changes the temporal patterns of circulating insulin concentration from transient to sustained. These results provide further insight into the pathogenesis of T2DM, and thus may contribute to develop better treatment of this condition.
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医学研究科
学術雑誌論文
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© The Author(s) 2018
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2056-7189
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関連情報
DOI
https://doi.org/10.1038/s41540-018-0051-6
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