神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90005683
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2024-04-27
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90005683 (fulltext)
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メタデータID
90005683
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open access
出版タイプ
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タイトル
Usefulness of hemoglobin A1c and glycated albumin measurements for insulinoma screening: an observational case-control study
著者
Torimoto, Keiichi ; Okada, Yosuke ; Tanaka, Yoshiya ; Matsuoka, Atsuko ; Hirota, Yushi ; Ogawa, Wataru ; Saisho, Yoshifumi ; Kurihara, Isao ; Itoh, Hiroshi ; Inada, Shinya ; Koga, Masafumi
著者名
Torimoto, Keiichi
著者名
Okada, Yosuke
著者名
Tanaka, Yoshiya
著者名
Matsuoka, Atsuko
著者ID
A1420
研究者ID
1000080566018
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8d8b694f29475700520e17560c007669
著者名
Hirota, Yushi
廣田, 勇士
ヒロタ, ユウシ
所属機関名
医学部附属病院
著者ID
A1358
研究者ID
1000040294219
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=38228987a3a438c8520e17560c007669
著者名
Ogawa, Wataru
小川, 渉
オガワ, ワタル
所属機関名
医学研究科
著者名
Saisho, Yoshifumi
著者名
Kurihara, Isao
著者名
Itoh, Hiroshi
著者名
Inada, Shinya
著者名
Koga, Masafumi
収録物名
BMC Cancer
巻(号)
19
ページ
174-174
出版者
BMC
刊行日
2019-02-26
公開日
2019-03-13
抄録
Background Insulinoma represents hypoglycemia as a predominant symptom; the autonomic symptoms may be resolved by chronically recurrent hypoglycemia resulting in the persistence of non-specific symptoms alone. Therefore, it has been estimated that there are many patients in whom the disease takes longer to diagnose and has remained undiagnosed. Although some parameters exist for the definitive diagnosis of the disease, there are currently no indices for early screening. Indices of glycemic control, hemoglobin A1c (HbA1c), and glycated albumin (GA) may be useful for the screening of patients with insulinoma having chronic hypoglycemia because the values become low in such a condition. Because there are no articles that have reported the point, we examine the effective cutoff values of HbA1c and GA for the diagnosis of insulinoma in the present study. Methods In a multicenter cross-sectional study, 31 patients with insulinoma were included for comparison with 120 control subjects with normal glucose tolerance based on 75g oral glucose tolerance tests whose characteristics were matched to the patients. The primary outcomes were optimal cutoff values of HbA1c and GA for the screening of insulinoma. Results HbA1c was significantly lower in the insulinoma group at 4.7 ± 0.4% compared to the healthy control group at 5.7 ± 0.3% (p<0.001), and GA was significantly lower in the insulinoma group at 11.6 ± 1.8% compared to the healthy control group at 14.5 ± 1.0%(p<0.001). According to a receiver operating characteristic (ROC) analysis, optimal cutoff values of HbA1c and GA for the diagnosis of insulinoma were 5.0 and 12.4%, respectively. Area under the curve values of HbA1c and GA were 0.970 and 0.929, respectively, showing no significant difference (p=0.399). Conclusions In the present study, HbA1c and GA values in patients with insulinoma were significantly lower compared to the healthy controls, and effective cutoff values for screening were shown in the diagnosis of insulinoma for the first time. HbA1c and GA can be useful indices for insulinoma screening. Because malignant insulinoma have a similar diagnostic process to that of benign insulinoma, these could be useful for malignant insulinoma.
キーワード
Insulinoma
HbA1c
Glycated albumin
Hypoglycemia
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© The Author(s). 2019
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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資源タイプ
journal article
言語
English (英語)
eISSN
1471-2407
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関連情報
DOI
https://doi.org/10.1186/s12885-019-5389-7
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