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https://hdl.handle.net/20.500.14094/90005756
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2024-03-29
05:25 集計
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90005756 (fulltext)
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メタデータID
90005756
アクセス権
open access
出版タイプ
Version of Record
タイトル
Metabolic Plasticity of Astrocytes and Aging of the Brain
著者
Morita, Mitsuhiro ; Ikeshima-Kataoka, Hiroko ; Kreft, Marko ; Vardjan, Nina ; Zorec, Robert ; Noda, Mami
著者ID
A0732
研究者ID
1000050297602
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.eb44d85269d72e68520e17560c007669.html
著者名
Morita, Mitsuhiro
森田, 光洋
モリタ, ミツヒロ
所属機関名
理学研究科
著者名
Ikeshima-Kataoka, Hiroko
著者名
Kreft, Marko
著者名
Vardjan, Nina
著者名
Zorec, Robert
著者名
Noda, Mami
収録物名
International Journal of Molecular Sciences
巻(号)
20(4)
ページ
941-941
出版者
MDPI
刊行日
2019-02-02
公開日
2019-03-29
抄録
As part of the blood-brain-barrier, astrocytes are ideally positioned between cerebral vasculature and neuronal synapses to mediate nutrient uptake from the systemic circulation. In addition, astrocytes have a robust enzymatic capacity of glycolysis, glycogenesis and lipid metabolism, managing nutrient support in the brain parenchyma for neuronal consumption. Here, we review the plasticity of astrocyte energy metabolism under physiologic and pathologic conditions, highlighting age-dependent brain dysfunctions. In astrocytes, glycolysis and glycogenesis are regulated by noradrenaline and insulin, respectively, while mitochondrial ATP production and fatty acid oxidation are influenced by the thyroid hormone. These regulations are essential for maintaining normal brain activities, and impairments of these processes may lead to neurodegeneration and cognitive decline. Metabolic plasticity is also associated with (re)activation of astrocytes, a process associated with pathologic events. It is likely that the recently described neurodegenerative and neuroprotective subpopulations of reactive astrocytes metabolize distinct energy substrates, and that this preference is supposed to explain some of their impacts on pathologic processes. Importantly, physiologic and pathologic properties of astrocytic metabolic plasticity bear translational potential in defining new potential diagnostic biomarkers and novel therapeutic targets to mitigate neurodegeneration and age-related brain dysfunctions.
キーワード
astrocyte
metabolism
glucose
fatty acid
insulin
noradrenaline
thyroid hormone
カテゴリ
理学研究科
学術雑誌論文
権利
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
ISSN
1661-6596
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eISSN
1422-0067
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関連情報
DOI
https://doi.org/10.3390/ijms20040941
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