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https://hdl.handle.net/20.500.14094/90005765
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2024-03-29
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90005765 (fulltext)
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90005765
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open access
出版タイプ
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タイトル
A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth
著者
Rappoport, Nadav ; Toung, Jonathan ; Hadley, Dexter ; Wong, Ronald J. ; Fujioka, Kazumichi ; Reuter, Jason ; Abbott, Charles W. ; Oh, Sam ; Hu, Donglei ; Eng, Celeste ; Huntsman, Scott ; Bodian, Dale L. ; Niederhuber, John E. ; Hong, Xiumei ; Zhang, Ge ; Sikora-Wohfeld, Weronika ; Gignoux, Christopher R. ; Wang, Hui ; Oehlert, John ; Jelliffe-Pawlowski, Laura L. ; Gould, Jeffrey B. ; Darmstadt, Gary L. ; Wang, Xiaobin ; Bustamante, Carlos D. ; Snyder, Michael P. ; Ziv, Elad ; Patsopoulos, Nikolaos A. ; Muglia, Louis J. ; Burchard, Esteban ; Shaw, Gary M. ; O'Brodovich, Hugh M. ; Stevenson, David K. ; Butte, Atul J. ; Sirota, Marina
著者名
Rappoport, Nadav
著者名
Toung, Jonathan
著者名
Hadley, Dexter
著者名
Wong, Ronald J.
著者ID
A0863
研究者ID
1000020568810
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.61a996a431fe1218520e17560c007669.html
著者名
Fujioka, Kazumichi
藤岡, 一路
フジオカ, カズミチ
所属機関名
医学部附属病院
著者名
Reuter, Jason
著者名
Abbott, Charles W.
著者名
Oh, Sam
著者名
Hu, Donglei
著者名
Eng, Celeste
著者名
Huntsman, Scott
著者名
Bodian, Dale L.
著者名
Niederhuber, John E.
著者名
Hong, Xiumei
著者名
Zhang, Ge
著者名
Sikora-Wohfeld, Weronika
著者名
Gignoux, Christopher R.
著者名
Wang, Hui
著者名
Oehlert, John
著者名
Jelliffe-Pawlowski, Laura L.
著者名
Gould, Jeffrey B.
著者名
Darmstadt, Gary L.
著者名
Wang, Xiaobin
著者名
Bustamante, Carlos D.
著者名
Snyder, Michael P.
著者名
Ziv, Elad
著者名
Patsopoulos, Nikolaos A.
著者名
Muglia, Louis J.
著者名
Burchard, Esteban
著者名
Shaw, Gary M.
著者名
O'Brodovich, Hugh M.
著者名
Stevenson, David K.
著者名
Butte, Atul J.
著者名
Sirota, Marina
収録物名
Scientific Reports
巻(号)
8
ページ
226-226
出版者
Nature Research
刊行日
2018-01-09
公開日
2019-03-29
抄録
Preterm birth (PTB), or the delivery prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. Although twin studies estimate that maternal genetic contributions account for approximately 30% of the incidence of PTB, and other studies reported fetal gene polymorphism association, to date no consistent associations have been identified. In this study, we performed the largest reported genome-wide association study analysis on 1,349 cases of PTB and 12,595 ancestry-matched controls from the focusing on genomic fetal signals. We tested over 2 million single nucleotide polymorphisms (SNPs) for associations with PTB across five subpopulations: African (AFR), the Americas (AMR), European, South Asian, and East Asian. We identified only two intergenic loci associated with PTB at a genome-wide level of significance: rs17591250 (P = 4.55E-09) on chromosome 1 in the AFR population and rs1979081 (P = 3.72E-08) on chromosome 8 in the AMR group. We have queried several existing replication cohorts and found no support of these associations. We conclude that the fetal genetic contribution to PTB is unlikely due to single common genetic variant, but could be explained by interactions of multiple common variants, or of rare variants affected by environmental influences, all not detectable using a GWAS alone.
カテゴリ
医学部附属病院
学術雑誌論文
権利
© The Author(s) 2017
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2045-2322
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関連情報
DOI
https://doi.org/10.1038/s41598-017-18246-5
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