神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90005766
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2024-04-19
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90005766 (fulltext)
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90005766
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open access
出版タイプ
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タイトル
Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model
著者
Htun, Yinmon ; Nakamura, Shinji ; Nakao, Yasuhiro ; Mitsuie, Tsutomu ; Nakamura, Makoto ; Yamato, Satoshi ; Jinnai, Wataru ; Koyano, Kosuke ; Ohta, Kenichi ; Morimoto, Aya ; Wakabayashi, Takayuki ; Sugino, Masashiro ; Fujioka, Kazumichi ; Kato, Ikuko ; Kondo, Sonoko ; Yasuda, Saneyuki ; Miki, Takanori ; Ueno, Masaki ; Kusaka, Takashi
著者名
Htun, Yinmon
著者名
Nakamura, Shinji
著者名
Nakao, Yasuhiro
著者名
Mitsuie, Tsutomu
著者名
Nakamura, Makoto
著者名
Yamato, Satoshi
著者名
Jinnai, Wataru
著者名
Koyano, Kosuke
著者名
Ohta, Kenichi
著者名
Morimoto, Aya
著者名
Wakabayashi, Takayuki
著者名
Sugino, Masashiro
著者ID
A0863
研究者ID
1000020568810
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=61a996a431fe1218520e17560c007669
著者名
Fujioka, Kazumichi
藤岡, 一路
フジオカ, カズミチ
所属機関名
医学部附属病院
著者名
Kato, Ikuko
著者名
Kondo, Sonoko
著者名
Yasuda, Saneyuki
著者名
Miki, Takanori
著者名
Ueno, Masaki
著者名
Kusaka, Takashi
収録物名
Scientific Reports
巻(号)
9
ページ
4088-4088
出版者
Nature Research
刊行日
2019-03-11
公開日
2019-03-29
抄録
Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to its antioxidant, anti-inflammatory, and antiapoptotic properties, the effectiveness of molecular hydrogen (H2) combined with TH was evaluated by means of neurological and histological assessments. Piglets were divided into three groups: hypoxic-ischaemic insult with normothermia (NT), insult with hypothermia (TH, 33.5 ± 0.5 °C), and insult with hypothermia with H2 ventilation (TH-H2, 2.1-2.7%). H2 ventilation and TH were administered for 24 h. After ventilator weaning, neurological assessment was performed every 6 h for 5 days. On day 5, the brains of the piglets were harvested for histopathological analysis. Regarding the neurological score, the piglets in the TH-H2 group consistently had the highest score from day 2 to 5 and showed a significantly higher neurological score from day 3 compared with the NT group. Most piglets in the TH-H2 group could walk at day 3 of recovery, whereas walking ability was delayed in the two other groups. The histological results revealed that TH-H2 tended to improve the status of cortical gray matter and subcortical white matter, with a considerable reduction in cell death. In this study, the combination of TH and H2 improved short-term neurological outcomes in neonatal hypoxic-ischaemic piglets.
カテゴリ
医学部附属病院
学術雑誌論文
権利
© The Author(s) 2019
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2045-2322
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関連情報
DOI
https://doi.org/10.1038/s41598-019-40674-8
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