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https://hdl.handle.net/20.500.14094/90005814
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2024-04-25
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90005814 (fulltext)
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メタデータID
90005814
アクセス権
open access
出版タイプ
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タイトル
The effects of resistance training on bone mineral density and bone quality in type 2 diabetic rats
著者
Ikedo, Aoi ; Kido, Kohei ; Ato, Satoru ; Sato, Koji ; Lee, Ji-Won ; Fujita, Satoshi ; Imai, Yuuki
著者名
Ikedo, Aoi
著者名
Kido, Kohei
著者名
Ato, Satoru
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Lee, Ji-Won
著者名
Fujita, Satoshi
著者名
Imai, Yuuki
収録物名
Physiological Reports
巻(号)
7(6)
ページ
e14046-e14046
出版者
Wiley
刊行日
2019-03
公開日
2019-04-11
抄録
Resistance training (RT) has been known to be effective in maintaining and improving bone strength, which is based on bone mineral density (BMD) and bone quality. However, it is not clear whether RT is effective in improving bone strength in patients with type-2 diabetes mellitus (T2DM), who have a high risk of fracture. Therefore, we tested the effects of a 6-week RT regimen using percutaneous electrical stimulation in T2DM model rats, male Otsuka Long-Evans Tokushima Fatty (OLETF), and its control, Long-Evans Tokushima Otsuka (LETO). After 6 weeks of RT, tibial BMD in RT legs was significantly higher than that in control (CON) legs in both groups. In diaphyseal cortical bone, bone area/tissue area, and cortical thickness was significantly increased in RT legs compared with CON legs in both groups. Cortical porosity was highly observed in OLETF compared with LETO, but RT improved cortical porosity in both groups. Interestingly, trabecular number, trabecular thickness and trabecular space as well as BMD and bone volume/tissue volume in proximal tibial metaphyseal trabecular bone were significantly improved in RT legs compared with CON legs in both groups. In contrast, connectivity density and structural model index were not affected by RT. These results indicate that the 6-week RT regimen effectively increased BMD and improved bone quality in T2DM model rats as well as control rats. Therefore, RT may have the potential to improve bone strength and reduce fracture risk, even in patients with T2DM.
キーワード
Bone mass
bone quality
resistance training
type-2 diabetes mellitus
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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資源タイプ
journal article
言語
English (英語)
eISSN
2051-817X
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関連情報
DOI
https://doi.org/10.14814/phy2.14046
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