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https://hdl.handle.net/20.500.14094/90005816
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2024-04-27
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90005816 (fulltext)
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メタデータID
90005816
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open access
出版タイプ
Version of Record
タイトル
Postprandial Blood Pressure Decrease in Patients with Type 2 Diabetes and Mild or Severe Cardiac Autonomic Dysfunction
著者
Hashizume, Masahiko ; Kinami, Saori ; Sakurai, Keiichi ; Izawa, P. Kazuhiro ; Shiotani, Hideyuki
著者名
Hashizume, Masahiko
著者名
Kinami, Saori
著者名
Sakurai, Keiichi
著者ID
A1350
研究者ID
1000010736185
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3330637c7f4d6307520e17560c007669
著者名
Izawa, P. Kazuhiro
井澤, 和大
イザワ, カズヒロ
所属機関名
保健学研究科
著者ID
A0760
研究者ID
1000000294231
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f9eba35c2f2c5cbf520e17560c007669
著者名
Shiotani, Hideyuki
塩谷, 英之
シオタニ, ヒデユキ
所属機関名
保健学研究科
収録物名
International Journal of Environmental Research and Public Health
巻(号)
16(5)
ページ
812-812
出版者
MDPI
刊行日
2019-03-01
公開日
2019-04-11
抄録
Background Few reports have evaluated the relationship between changes in postprandial blood pressure and the severity of autonomic dysfunction in patients with type 2 diabetes. This was a cross-sectional study designed to investigate postprandial blood pressure changes in individuals without type 2 diabetes and patients with type 2 diabetes and mild or severe cardiac autonomic dysfunction. Methods Forty patients with type 2 diabetes mellitus and 20 individuals without type 2 diabetes participated in this study. Fifty-two participants underwent a meal tolerance test. Blood pressure (brachial systolic blood pressure (bSBP) and central systolic blood pressure (cSBP)), electrocardiogram recordings, and blood samples were assessed before and after meal ingestion. Patients with diabetes were divided into two groups based on their coefficient of variation of R–R intervals (CVRR): a normal or mildly dysfunctional group (mild group, CVRR ≥ 2%; n = 20) and a severely dysfunctional group (severe group, CVRR < 2%; n = 15). Results In the control group, bSBP and cSBP did not significantly change after meal ingestion, whereas both decreased significantly at 60 min after meal ingestion in the mild and severe groups. While blood pressure recovered at 120 min after meal ingestion in the mild group, a significant decrease in blood pressure persisted at 120 min after meal ingestion in the severe group. Conclusions Based on these results, adequate clinical attention should be paid to the risk of serious events related to postprandial decreases in blood pressure, particularly in patients with diabetes and severe cardiac autonomic dysfunction.
キーワード
postprandial hypotension
diabetic autonomic neuropathy
blood pressure
type 2 diabetes mellitus
カテゴリ
保健学研究科
学術雑誌論文
権利
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
ISSN
1661-7827
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eISSN
1660-4601
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関連情報
DOI
https://doi.org/10.3390/ijerph16050812
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