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https://hdl.handle.net/20.500.14094/90005824
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2024-03-29
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90005824 (fulltext)
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メタデータID
90005824
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open access
出版タイプ
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タイトル
Effect of Mixed Meal and Leucine Intake on Plasma Amino Acid Concentrations in Young Men
著者
Yoshii, Naomi ; Sato, Koji ; Ogasawara, Riki ; Nishimura, Yusuke ; Shinohara, Yasushi ; Fujita, Satoshi
著者名
Yoshii, Naomi
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.b09e77be63b04dce520e17560c007669.html
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Ogasawara, Riki
著者名
Nishimura, Yusuke
著者名
Shinohara, Yasushi
著者名
Fujita, Satoshi
収録物名
Nutrients
巻(号)
10(10)
ページ
1543-1543
出版者
MDPI
刊行日
2018-10
公開日
2019-04-11
抄録
Dietary protein intake is critical for the maintenance of skeletal muscle mass. Plasma amino acid concentrations increase with protein intake and increases in muscle protein synthesis are dependent on leucine concentrations. We aimed to investigate the effect of a mixed meal and free amino acids intake on plasma leucine concentrations. In this randomized crossover study, 10 healthy young men (age 25 ± 1 years, height 1.73 ± 0.02 m, weight 65.8 ± 1.5 kg) underwent tests under different conditions—intake of 2 g of leucine (LEU), intake of a mixed meal (protein 27.5 g, including 2.15 g of leucine, protein: fat: carbohydrate ratio—22:25:53) only (MEAL), intake of 2 g of leucine immediately after a mixed meal (MEAL-LEU) and intake of 2 g of leucine 180 min after a mixed meal (MEAL-LEU180). Blood samples were collected within 420 min (240 min for LEU only) after intake and changes in amino acid concentrations were evaluated. Although the maximum plasma leucine concentration increased to 442 ± 24 µM for LEU, it was lower at 347 ± 16 µM (p < 0.05 vs. LEU) for MEAL-LEU, 205 ± 8 µM (p < 0.05 vs. LEU) for MEAL. The maximum plasma leucine concentration for MEAL-LEU180 increased to 481 ± 27 µM and compared to LEU there was no significant difference (p > 0.1). The observation that rapid elevations in plasma leucine concentrations are suppressed when leucine is ingested at the same time as a meal suggests that the timing of its intake must be considered to maximize the anabolic response.
キーワード
leucine concentration
protein intake
mixed meal intake
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
eISSN
2072-6643
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関連情報
DOI
https://doi.org/10.3390/nu10101543
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