神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90005949
このアイテムのアクセス数:
15
件
(
2024-04-20
22:03 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90005949 (fulltext)
pdf
191 KB
11
メタデータ
ファイル出力
メタデータID
90005949
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model
著者
Sato, Koji ; Fujita, Satoshi ; Iemitsu, Motoyuki
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Fujita, Satoshi
著者名
Iemitsu, Motoyuki
収録物名
The FASEB Journal
巻(号)
31(2)
ページ
793-801
出版者
Federation of American Societies for Experimental Biology
刊行日
2017-02
公開日
2019-05-14
抄録
The effects of chronic Dioscorea esculenta administration and exercise training on muscle sex steroid hormone levels and insulin resistance in type 2 diabetes rats was assessed. Twenty-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were assigned randomly to the control, D. esculenta treatment, D. esculenta with 5α-reductase inhibitor treatment, or the exercise training groups (running at 25 m/min for 1 h, 5 d/wk; n = 10 each group). Eight weeks of D. esculenta treatment or exercise training significantly attenuated the increase in plasma insulin and fasting glucose levels. Plasma and muscle concentrations of dehydroepiandrosterone and 5α-dihydrotestosterone (DHT) and the expression of 5α-reductase increased significantly in the D. esculenta-treated and exercise training groups, and both treatments led to the upregulation of glucose transporter-4 translocation with concomitant increases in PKB and PKC-ζ/λ phosphorylation. Furthermore, the glucose metabolic clearance rate, which represents insulin sensitivity, increased significantly in both the D. esculenta-treated and exercise training groups. These effects were suppressed by administration of the DHT synthetic inhibitor. Together, these findings suggest that the D. esculenta-induced increase in muscle sex steroid hormone levels helps decrease insulin resistance in type 2 diabetes.—Sato, K., Fujita, S., Iemitsu, M. Dioscorea esculenta–induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model.
キーワード
diosgenin
insulin resistance
exercise
DHT
カテゴリ
人間発達環境学研究科
学術雑誌論文
詳細を表示
資源タイプ
journal article
言語
English (英語)
ISSN
0892-6638
OPACで所蔵を検索
CiNiiで学外所蔵を検索
eISSN
1530-6860
OPACで所蔵を検索
CiNiiで学外所蔵を検索
NCID
AA1066874X
OPACで所蔵を検索
CiNiiで表示
関連情報
DOI
https://doi.org/10.1096/fj.201600874R
ホームへ戻る