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https://hdl.handle.net/20.500.14094/90006159
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2024-04-25
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90006159 (fulltext)
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90006159
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open access
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タイトル
Raftophilic rhodopsin-clusters offer stochastic platforms for G protein signalling in retinal discs
著者
Hayashi, Fumio ; Saito, Natsumi ; Tanimoto, Yasushi ; Okada, Keisuke ; Morigaki, Kenichi ; Seno, Keiji ; Maekawa, Shohei
著者名
Hayashi, Fumio
林, 文夫
ハヤシ, フミオ
著者名
Saito, Natsumi
著者名
Tanimoto, Yasushi
著者名
Okada, Keisuke
著者ID
A1236
研究者ID
1000010358179
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f6c039bc884596f8520e17560c007669
著者名
Morigaki, Kenichi
森垣, 憲一
モリガキ, ケンイチ
所属機関名
バイオシグナル総合研究センター
著者名
Seno, Keiji
著者ID
A0269
研究者ID
1000040173695
著者名
Maekawa, Shohei
前川, 昌平
マエカワ, ショウヘイ
所属機関名
理学研究科
収録物名
Communications Biology
巻(号)
2
ページ
209-209
出版者
Nature Research
刊行日
2019-06-14
公開日
2019-07-08
抄録
Rhodopsin is a G protein-coupled receptor (GPCR) that initiates the phototransduction cascade in retinal disc membrane. Recent studies have suggested that rhodopsin forms highly ordered rows of dimers responsible for single-photon detection by rod photoreceptors. Dimerization is also known to confer to rhodopsin a high affinity for ordered lipids (raftophilicity). However, the role of rhodopsin organization and its raftophilicity in phototransduction remains obscure, owing to the lack of direct observation of rhodopsin dynamics and distribution in native discs. Here, we explore the single-molecule and semi-multimolecule behaviour of rhodopsin in native discs. Rhodopsin forms transient meso-scale clusters, even in darkness, which are loosely confined to the disc centre. Cognate G protein transducin co-distributes with rhodopsin, and exhibits lateral translocation to the disc periphery upon activation. We demonstrate that rhodopsin offers inherently distributed and stochastic platforms for G protein signalling by self-organizing raftophilic clusters, which continually repeat generation/extinction in the disc membrane.
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バイオシグナル総合研究センター
理学研究科
学術雑誌論文
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© The Author(s) 2019.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2399-3642
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関連情報
DOI
https://doi.org/10.1038/s42003-019-0459-6
URI
http://www.kobe-u.ac.jp/research_at_kobe/NEWS/news/2019_06_14_01.html
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