神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90006330
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2024-04-19
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90006330 (fulltext)
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メタデータID
90006330
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open access
出版タイプ
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タイトル
Leptin mediates the relationship between fat mass and blood pressure The Hamamatsu School-based health study
著者
Fujita, Yuki ; Kouda, Katsuyasu ; Ohara, Kumiko ; Nakamura, Harunobu ; Iki, Masayuki
著者名
Fujita, Yuki
著者名
Kouda, Katsuyasu
著者名
Ohara, Kumiko
著者ID
A0031
研究者ID
1000010322140
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=ea6c07a8586cffa3520e17560c007669
著者名
Nakamura, Harunobu
中村, 晴信
ナカムラ, ハルノブ
所属機関名
人間発達環境学研究科
著者名
Iki, Masayuki
収録物名
Medicine
巻(号)
98(12)
ページ
e14934-e14934
出版者
Wolters Kluwer Health
刊行日
2019-03
公開日
2019-09-13
抄録
Animal studies have shown that leptin mediates the association between obesity and hypertension. However, only a few studies have assessed this relationship in population-based epidemiological studies. This study aimed to determine whether leptin mediates the relationship between body fat and blood pressure in school-aged children. A cross-sectional survey was conducted among school-aged children in Hamamatsu, Japan. Body fat was measured using dual-energy X-ray absorptiometry. Height-normalized index of fat mass (fat mass index) was calculated by dividing fat mass by height squared. Serum leptin levels were measured by enzyme-linked immunosorbent assay. Multiple regression analysis was used to evaluate relationships between body fat, serum leptin levels, and blood pressure. The mediating effect of leptin on the association between body fat and blood pressure was assessed by causal mediation analysis and regression analysis. Both fat mass index and leptin were significantly and positively associated with blood pressure. Fat mass index was also strongly associated with serum leptin levels. Body fat and blood pressure were no longer associated after adjusting for leptin. These findings suggest that the association between body fat and blood pressure is mediated by leptin. Of the total effect of fat mass index on blood pressure, the mediating effect of leptin accounted for 78.6% (P = .03) in boys and 42.2% (P = .11) in girls. Our findings suggest that body fat is associated with blood pressure, and this association is mediated by leptin. Thus, leptin acts as a mediator that links body adiposity with blood pressure elevation in school-aged children.
キーワード
adipose tissue
blood pressure
child
densitometry
leptin
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2019 the Author(s). Published by Wolters Kluwer Health, Inc.
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NCND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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資源タイプ
journal article
言語
English (英語)
ISSN
0025-7974
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eISSN
1536-5964
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NCID
AA00728867
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関連情報
DOI
https://doi.org/10.1097/MD.0000000000014934
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