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https://hdl.handle.net/20.500.14094/90006397
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2024-04-25
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90006397 (fulltext)
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メタデータID
90006397
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open access
出版タイプ
Version of Record
タイトル
Transmission dynamics of HIV-1 subtype B strains in Indonesia
著者
Ueda, Shuhei ; Witaningrum, Adiana Mutamsari ; Khairunisa, Siti Qamariyah ; Kotaki, Tomohiro ; Motomura, Kazushi ; Nasronudin ; Kameoka, Masanori
著者名
Ueda, Shuhei
著者名
Witaningrum, Adiana Mutamsari
著者名
Khairunisa, Siti Qamariyah
著者ID
A1352
研究者ID
1000010758816
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=849783d0576b0945520e17560c007669
著者名
Kotaki, Tomohiro
小瀧, 将裕
コタキ, トモヒロ
所属機関名
保健学研究科
著者名
Motomura, Kazushi
著者名
Nasronudin
著者ID
A0045
研究者ID
1000060281838
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=01cae9e1f2290a00520e17560c007669
著者名
Kameoka, Masanori
亀岡, 正典
カメオカ, マサノリ
所属機関名
保健学研究科
収録物名
Scientific Reports
巻(号)
9
ページ
13986-13986
出版者
Nature Research
刊行日
2019-09-27
公開日
2019-10-16
抄録
Human immunodeficiency virus type 1 (HIV-1) and acquired immunodeficiency syndrome (AIDS) represent a major public health concern in Indonesia. Although circulating recombinant form (CRF) 01_AE is a predominant subtype in Indonesia, HIV-1 subtype B (HIV-1B) is also widely prevalent. However, the viral genetic evolution, spatial origins, and patterns of transmission of HIV-1B in Indonesia remain unclear. In the present study, we described the evolutionary characteristics and spatial-temporal transmission networks of HIV-1B in Indonesia. To elucidate the epidemiological link between HIV-1B epidemics in Indonesia and those in the remainder of the world, we conducted phylogenetic analyses of HIV-1B strains in Indonesia. Based on the results obtained, at least three epidemic clades [the Indonesia, United States (US), and China clades] of HIV-1B were found to be prevalent in Indonesia. In order to identify the potential source and transmission route of Indonesian HIV-1B strains, we performed Bayesian analyses and constructed Maximum Glade credibility trees of each Glade. Although some HIV-1B strains in Indonesia were introduced from Thailand, the prevalent HIV-1B strains appeared to have been directly introduced from Europe or America. Indonesian HIV-1B may have spread via the main dispersal of pandemic HIV-1B strains via the US from the Caribbean region rather than being directly introduced from Africa.
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保健学研究科
学術雑誌論文
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© The Author(s) 2019.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2045-2322
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関連情報
DOI
https://doi.org/10.1038/s41598-019-50491-8
URI
https://www.kobe-u.ac.jp/research_at_kobe/NEWS/news/2019_09_27_01.html
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