神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90006409
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2024-04-26
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90006409 (fulltext)
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メタデータID
90006409
アクセス権
open access
出版タイプ
Version of Record
タイトル
Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction
著者
Nemoto, Shinji ; Kasahara, Yusuke ; Izawa, P. Kazuhiro ; Watanabe, Satoshi ; Yoshizawa, Kazuya ; Takeichi, Naoya ; Kamiya, Kentaro ; Suzuki, Norio ; Omiya, Kazuto ; Matsunaga, Atsuhiko ; Akashi, Yoshihiro J.
著者名
Nemoto, Shinji
著者名
Kasahara, Yusuke
著者ID
A1350
研究者ID
1000010736185
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3330637c7f4d6307520e17560c007669
著者名
Izawa, P. Kazuhiro
井澤, 和大
イザワ, カズヒロ
所属機関名
保健学研究科
著者名
Watanabe, Satoshi
著者名
Yoshizawa, Kazuya
著者名
Takeichi, Naoya
著者名
Kamiya, Kentaro
著者名
Suzuki, Norio
著者名
Omiya, Kazuto
著者名
Matsunaga, Atsuhiko
著者名
Akashi, Yoshihiro J.
収録物名
International Journal of Environmental Research and Public Health
巻(号)
16(16)
ページ
2838-2838
出版者
MDPI
刊行日
2019-08
公開日
2019-10-21
抄録
A simplified substitute for heart rate (HR) at the anaerobic threshold (AT), i.e., resting HR plus 30 beats per minute or a percentage of predicted maximum HR, is used as a way to determine exercise intensity without cardiopulmonary exercise testing (CPX) data. However, difficulties arise when using this method in subacute myocardial infarction (MI) patients undergoing beta-blocker therapy. This study compared the effects of αβ-blocker and β1-blocker treatment to clarify how different beta blockers affect HR response during incremental exercise. MI patients were divided into αβ-blocker (n = 67), β1-blocker (n = 17), and no-β-blocker (n = 47) groups. All patients underwent CPX one month after MI onset. The metabolic chronotropic relationship (MCR) was calculated as an indicator of HR response from the ratio of estimated HR to measured HR at AT (MCR-AT) and peak exercise (MCR-peak). MCR-AT and MCR-peak were significantly higher in the αβ-blocker group than in the β1-blocker group (p < 0.001, respectively). Multiple regression analysis revealed that β1-blocker but not αβ-blocker treatment significantly predicted lower MCR-AT and MCR-peak (β = -0.432, p < 0.001; β = -0.473, p < 0.001, respectively). Based on these results, when using the simplified method, exercise intensity should be prescribed according to the type of beta blocker used.
キーワード
myocardial infarction
beta-blocker
metabolic chronotropic relationship
chronotropic index
heart rate response
cardiac rehabilitation
カテゴリ
保健学研究科
学術雑誌論文
権利
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
ISSN
1661-7827
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eISSN
1660-4601
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関連情報
DOI
https://doi.org/10.3390/ijerph16162838
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