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https://hdl.handle.net/20.500.14094/90006933
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2024-03-29
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90006933 (fulltext)
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メタデータID
90006933
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open access
出版タイプ
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タイトル
Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan
著者
Kouda, Katsuyasu ; Iki, Masayuki ; Ohara, Kumiko ; Nakamura, Harunobu ; Fujita, Yuki ; Nishiyama, Toshimasa
著者名
Kouda, Katsuyasu
著者名
Iki, Masayuki
著者名
Ohara, Kumiko
著者ID
A0031
研究者ID
1000010322140
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.ea6c07a8586cffa3520e17560c007669.html
著者名
Nakamura, Harunobu
中村, 晴信
ナカムラ, ハルノブ
所属機関名
人間発達環境学研究科
著者名
Fujita, Yuki
著者名
Nishiyama, Toshimasa
収録物名
Journal of Physiological Anthropology
巻(号)
38(1)
ページ
16-16
出版者
BMC
刊行日
2019-12-05
公開日
2020-03-19
抄録
Background: Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bone status during puberty. Methods: We analyzed prospective 3-year follow-up data of 254 community-dwelling children who completed both baselines (at age 11.2 years) and follow-up (at age 14.2 years) surveys in Hamamatsu, Japan. Total body (TB) bone area and bone mineral parameters were assessed using dual-energy X-ray absorptiometry. Results: During the 3-year follow-up period, there were significant (P < 0.05) increases in total body less head (TBLH) areal bone mineral density (aBMD), TBLH bone mineral content (BMC), and TB bone area, and a significant decrease in TB bone mineral apparent density (BMAD, volumetric bone mineral density, vBMD). IGF-I levels showed significant positive relationships with TBLH BMC and TBLH aBMD at both baseline and follow-up. TBLH aBMD in boys and TB BMAD in girls at follow-up showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. Similarly, changes in TBLH aBMD in boys and TB BMAD in girls during the 3-year follow-up period showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. Conclusions: These results suggest that pubertal children with high levels of serum IGF-I tended to have high bone mineral acquisition later on.
キーワード
Bone development
Densitometry
General population
Somatomedins
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© The Author(s). 2019
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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資源タイプ
journal article
言語
English (英語)
eISSN
1880-6805
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関連情報
DOI
https://doi.org/10.1186/s40101-019-0210-5
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