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https://hdl.handle.net/20.500.14094/90007048
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2024-03-29
10:04 集計
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90007048 (fulltext)
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メタデータID
90007048
アクセス権
open access
出版タイプ
Version of Record
タイトル
Relationship between Serum Vitamin D and Leg Strength in Older Adults with Pre-Dialysis Chronic Kidney Disease: A Preliminary Study
著者
Saito, Akira ; Hiraki, Koji ; Otobe, Yuhei ; Izawa, P. Kazuhiro ; Sakurada, Tsutomu ; Shibagaki, Yugo
著者名
Saito, Akira
著者名
Hiraki, Koji
著者名
Otobe, Yuhei
著者ID
A1350
研究者ID
1000010736185
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.3330637c7f4d6307520e17560c007669.html
著者名
Izawa, P. Kazuhiro
井澤, 和大
イザワ, カズヒロ
所属機関名
保健学研究科
著者名
Sakurada, Tsutomu
著者名
Shibagaki, Yugo
収録物名
International Journal of Environmental Research and Public Health
巻(号)
17(4)
ページ
1433-1433
出版者
MDPI
刊行日
2020-02
公開日
2020-04-23
抄録
Active vitamin D (calcitriol, or 1.25 (OH) 2 D) is associated with muscle weakness, falls, and fracture in community-dwelling older people. This study aimed to investigate the relationship between a serum active vitamin D level and lower extremity muscle strength in elderly patients with pre-dialysis chronic kidney disease (CKD). This cross-sectional study included 231 patients with CKD treated conservatively as outpatients. We analyzed patient background factors, including age, sex, body mass index (BMI), intact parathyroid hormone (PTH), phosphorus, calcium, albumin, serum calcitriol level as an indicator of active vitamin D, and estimated glomerular filtration rate (eGFR) collected from medical records. As an index of lower extremity muscle strength, the isometric knee extension muscle strength-to-weight ratio (kgf/kg) was calculated. The mean patient age was 75.9 ± 6.1 years (68.8% male), and the BMI was 24.1 ± 3.8 kg/m2. A significant correlation was observed between knee extensor muscle strength and serum calcitriol level (r = 0.32, p < 0.01), age (r = –0.30, p < 0.01), BMI (r = −0.31, p < 0.01), intact PTH (r = −0.22, p < 0.01), phosphorus (r = −0.29, p < 0.01), albumin (r = −0.28, p < 0.01), and eGFR (r = 0.25, p < 0.01). Multiple regression analysis showed calcitriol to be significantly associated with knee extensor muscle strength (β: 0.14, 95% confidence interval: 0–0.002, p = 0.04) after adjustment for covariates. These results suggest that the serum active vitamin D level is associated with lower extremity muscle strength in older adults with pre-dialysis CKD. It is necessary to verify whether vitamin D supplementation increases lower extremity muscle strength in pre-dialysis CKD patients.
キーワード
serum vitamin D
leg strength
older adults
pre-dialysis chronic kidney disease
カテゴリ
保健学研究科
学術雑誌論文
権利
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
ISSN
1661-7827
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eISSN
1660-4601
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関連情報
DOI
https://doi.org/10.3390/ijerph17041433
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