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https://hdl.handle.net/20.500.14094/90007080
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2024-03-29
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90007080 (fulltext)
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メタデータID
90007080
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open access
出版タイプ
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タイトル
Transient microglial absence assists postmigratory cortical neurons in proper differentiation
著者
Hattori, Yuki ; Naito, Yu ; Tsugawa, Yoji ; Nonaka, Shigenori ; Wake, Hiroaki ; Nagasawa, Takashi ; Kawaguchi, Ayano ; Miyata, Takaki
著者名
Hattori, Yuki
著者名
Naito, Yu
著者名
Tsugawa, Yoji
著者名
Nonaka, Shigenori
著者ID
A0029
研究者ID
1000090455220
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.0dd6999dcebbbf8b520e17560c007669.html
著者名
Wake, Hiroaki
和氣, 弘明
ワケ, ヒロアキ
所属機関名
先端融合研究環
著者名
Nagasawa, Takashi
著者名
Kawaguchi, Ayano
著者名
Miyata, Takaki
収録物名
Nature Communications
巻(号)
11(1)
ページ
1631-1631
出版者
Nature Research
刊行日
2020-04-02
公開日
2020-05-08
抄録
In the developing cortex, postmigratory neurons accumulate in the cortical plate (CP) to properly differentiate consolidating subtype identities. Microglia, despite their extensive surveying activity, temporarily disappear from the midembryonic CP. However, the mechanism and significance of this absence are unknown. Here, we show that microglia bidirectionally migrate via attraction by CXCL12 released from the meninges and subventricular zone and thereby exit the midembryonic CP. Upon nonphysiological excessive exposure to microglia in vivo or in vitro, young postmigratory and in vitro-grown CP neurons showed abnormal differentiation with disturbed expression of the subtype-associated transcription factors and genes implicated in functional neuronal maturation. Notably, this effect is primarily attributed to interleukin 6 and type I interferon secreted by microglia. These results suggest that "sanctuarization" from microglia in the midembryonic CP is required for neurons to appropriately fine-tune the expression of molecules needed for proper differentiation, thus securing the establishment of functional cortical circuit.
カテゴリ
先端融合研究環
学術雑誌論文
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© The Author(s) 2020
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
eISSN
2041-1723
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NCID
AA12645905
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関連情報
DOI
https://doi.org/10.1038/s41467-020-15409-3
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