神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90007094
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2024-04-19
18:04 集計
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90007094 (fulltext)
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メタデータID
90007094
アクセス権
open access
出版タイプ
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タイトル
Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats
著者
Onaru, Kanoko ; Ohno, Shuji ; Kubo, Shizuka ; Nakanishi, Satoki ; Hirano, Tetsushi ; Mantani, Youhei ; Yokoyama, Toshifumi ; Hoshi, Nobuhiko
著者名
Onaru, Kanoko
著者名
Ohno, Shuji
著者名
Kubo, Shizuka
著者名
Nakanishi, Satoki
著者名
Hirano, Tetsushi
著者ID
A1072
研究者ID
1000030724984
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=baf1f569c1518783520e17560c007669
著者名
Mantani, Youhei
万谷, 洋平
マンタニ, ヨウヘイ
所属機関名
農学研究科
著者ID
A0061
研究者ID
1000010380156
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=158c55140a1540e9520e17560c007669
著者名
Yokoyama, Toshifumi
横山, 俊史
ヨコヤマ, トシフミ
所属機関名
農学研究科
著者ID
A0039
研究者ID
1000010209223
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fa741cc09ab44f05520e17560c007669
著者名
Hoshi, Nobuhiko
星, 信彦
ホシ, ノブヒコ
所属機関名
農学研究科
収録物名
Journal of Veterinary Medical Science
巻(号)
82(3)
ページ
360-372
出版者
Japanese Society of Veterinary Science
刊行日
2020-03
公開日
2020-05-14
抄録
Neonicotinoid pesticides (NNs) act as agonists on nicotinic acetylcholine receptors (nAChRs) of insects, and there have been concerns about the effects of NNs on the health of mammals. Since nAChRs are expressed in immune cells, it is possible that NNs disturb the immune system. However, few reports have examined the immunotoxicity of clothianidin (CLO), a widely-used NN. Here, we report the effects of CLO on immune organs and type IV allergic reactions in ear auricles. We orally administered CLO at 0, 30 and 300 mg/kg/day (CLO-0, 30 and 300) to Sprague-Dawley rats for 28 days. The effects were evaluated by organ and body weights, histopathology, and immunohistochemistry (TCRαβ, CD4, CD8, CD11b, CD68, CD103). In addition, some cecal contents were subjected to preliminary gut microbiota analysis, because microbiota contribute to host homeostasis, including the immunity. Our results showed loose stool, suppression of body weight gain, significant changes in organ weights (thymus: decreased; liver: increased) and changes of the gut microbiota in the CLO-300 group. There were no obvious histopathological changes in immune organs. Granulomas of the ear auricles were found in one rat of each of the CLO-30 and 300 groups, but CLO had no apparent effect on the thickness or immunohistochemistry in the ear auricles. We present new evidence that CLO affects the thymus and intestine, and might enhance the local inflammatory response. These findings should contribute to the appropriate evaluation of the safety of NNs in the future.
キーワード
allergic reaction
clothianidin
gut microbiota
rat
thymus
カテゴリ
農学研究科
学術雑誌論文
権利
©2020 The Japanese Society of Veterinary Science.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
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資源タイプ
journal article
言語
English (英語)
ISSN
0916-7250
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eISSN
1347-7439
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NCID
AA11510037
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関連情報
DOI
https://doi.org/10.1292/jvms.19-0689
NAID
130007814905
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