神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90007218
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2024-04-21
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90007218
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open access
出版タイプ
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タイトル
Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study
著者
Hasegawa, Takumi ; Iga, Tomoya ; Takeda, Daisuke ; Amano, Rika ; Saito, Izumi ; Kakei, Yasumasa ; Kusumoto, Junya ; Kimoto, Akira ; Sakakibara, Akiko ; Akashi, Masaya
著者ID
A1489
研究者ID
1000050546497
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=322ffbb7f3848e30520e17560c007669
著者名
Hasegawa, Takumi
長谷川, 巧実
ハセガワ, タクミ
所属機関名
医学研究科
著者名
Iga, Tomoya
著者ID
A2567
研究者ID
1000080755637
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f59f62b200a1f47c520e17560c007669
著者名
Takeda, Daisuke
武田, 大介
タケダ, ダイスケ
所属機関名
医学部附属病院
著者名
Amano, Rika
著者名
Saito, Izumi
著者ID
A2217
研究者ID
1000070772896
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3e2a39a5f4448ccc520e17560c007669
著者名
Kakei, Yasumasa
筧, 康正
カケイ, ヤスマサ
所属機関名
医学部附属病院
著者名
Kusumoto, Junya
著者ID
A2386
研究者ID
1000030597167
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=c598b50157255250520e17560c007669
著者名
Kimoto, Akira
木本, 明
キモト, アキラ
所属機関名
医学部附属病院
著者ID
A1515
研究者ID
1000000569866
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=edf6c833915a253f520e17560c007669
著者名
Sakakibara, Akiko
榊原, 晶子
サカキバラ, アキコ
所属機関名
医学部附属病院
著者ID
A1492
研究者ID
1000040597168
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b7649a2950dc725a520e17560c007669
著者名
Akashi, Masaya
明石, 昌也
アカシ, マサヤ
所属機関名
医学研究科
収録物名
BMC Cancer
巻(号)
20(1)
ページ
568-568
出版者
BMC
刊行日
2020-06-17
公開日
2020-07-14
抄録
Background Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. Methods This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. Results In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59–5.19, P< 0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32–4.25, P< 0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13–3.35, P=0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42–3.72, P< 0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07–2.76, P=0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13–2.84, P=0.013) were independent predictors of overall survival. Conclusions Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.
キーワード
Neutrophil-to-lymphocyte ratio
Lymphocyte-to-monocyte ratio
Platelet-to-lymphocyte ratio
Oral squamous cell carcinoma
Overall survival
Disease-specific survival
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© The Author(s) 2020.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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journal article
言語
English (英語)
eISSN
1471-2407
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NCID
AA12034763
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関連情報
DOI
https://doi.org/10.1186/s12885-020-07063-1
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