神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90007226
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2024-04-27
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90007226 (fulltext)
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メタデータID
90007226
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open access
出版タイプ
Version of Record
タイトル
Comparison of 11C-choline Positron Emission Tomography/Computed Tomography (PET/CT) and Conventional Imaging for Detection of Recurrent Prostate Cancer
著者
Kawanaka, Yusuke ; Kitajima, Kazuhiro ; Yamamoto, Shingo ; Nakanishi, Yukako ; Yamada, Yusuke ; Hashimoto, Takahiko ; Suzuki, Toru ; Go, Shuken ; Kanematsu, Akihiro ; Nojima, Michio ; Sofue, Keitaro ; Trsurusaki, Masakatsu ; Tamaki, Yukihisa ; Yoshida, Rika ; Yamakado, Koichiro
著者名
Kawanaka, Yusuke
著者名
Kitajima, Kazuhiro
著者名
Yamamoto, Shingo
著者名
Nakanishi, Yukako
著者名
Yamada, Yusuke
著者名
Hashimoto, Takahiko
著者名
Suzuki, Toru
著者名
Go, Shuken
著者名
Kanematsu, Akihiro
著者名
Nojima, Michio
著者ID
A1469
研究者ID
1000090622027
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f7fcd4a60d373990520e17560c007669
著者名
Sofue, Keitaro
祖父江, 慶太郎
ソフエ, ケイタロウ
所属機関名
医学部附属病院
著者名
Trsurusaki, Masakatsu
著者名
Tamaki, Yukihisa
著者名
Yoshida, Rika
著者名
Yamakado, Koichiro
収録物名
Cureus
巻(号)
10(7)
ページ
e2966-e2966
出版者
Cureus, Inc.
刊行日
2018-07-11
公開日
2020-07-14
抄録
We aimed to compare 11C-choline positron emission tomography/computed tomography (PET/CT) with conventional imaging, including pelvic magnetic resonance imaging (MRI), contrast-enhanced chest, abdomen, and pelvic computed tomography (CT), and bone scintigraphy, for prostate cancer restaging. Thirty patients (median prostate-specific antigen [PSA: 11.8 ng/mL]) with suspected recurrent prostate cancer following definitive treatment underwent 11C-choline PET/CT and conventional imaging, including pelvic MRI, contrast-enhanced chest, abdomen, and pelvic CT, and bone scintigraphy. The results were compared with regard to patient- and lesion-based diagnostic performance for local recurrence, and for lymph node and bony metastases using receiver operating characteristic (ROC) analysis and McNemar’s test. Documented local recurrence and node and bony metastases were present in 11 (36.7%), 10 (33.3%), and 17 (56.7%) cases, respectively, of the enrolled patients. Patient-based sensitivity/specificity/accuracy/area under the ROC curve for 11C-choline-PET/CT for diagnosing local recurrence were 90.9%/94.7%/93.3%/0.975 and for conventional imaging were 90.9%/100%/96.7%/1.0. Those who underwent 11C-choline-PET/CT for node metastasis were 90.0%/95.0%/93.3%/0.925 and for conventional imaging were 70.0%/95.0%/86.7%/0.905. Those who underwent 11C-choline-PET/CT for bone metastasis were 94.1%/92.3%/93.3%/0.991 and who underwent conventional imaging were 94.1%/84.6%/90.0%/0.982. No significant differences were observed among them. The lesion-based detection rate of 11C-choline PET/CT for local recurrences and node and bone metastases as compared to conventional imaging was 92.9% (13/14) vs. 92.9% (13/14); 87.1% (27/31) vs. 54.8% (17/31); and 96.9% (219/226) vs. 90.3% (204/226) respectively, with significant differences noted for detection of node and bone lesions (p=0.0044 and p=0.00030, respectively). 11C-choline-PET/CT is more accurate in the detection of recurrent prostate cancer nodes and bony metastatic lesions compared to conventional imaging and has the advantage of restaging the disease in a single step.
キーワード
prostate cancer
recurrence
choline pet
ct
mri
bone scintigraphy
カテゴリ
医学部附属病院
学術雑誌論文
権利
© Copyright 2018Kawanaka et al.
This is an openaccess article distributed under theterms of the Creative CommonsAttribution License CC-BY 3.0.,which permits unrestricted use,distribution, and reproduction in anymedium, provided the originalauthor and source are credited.
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資源タイプ
journal article
言語
English (英語)
eISSN
2168-8184
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関連情報
DOI
https://doi.org/10.7759/cureus.2966
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