90007298

open access

Accepted Manuscript

Intracellular self-assembly of supramolecular gelators to selectively kill cells of interest

Polymer Journal

52(8)

883-889

Springer Nature

2020-08

2020-11-01

Published online : 13 April 2020

The significant progress in supramolecular chemistry since the end of last century includes the development of supramolecular gels. In particular, the spatiotemporal self-assembly of synthetic small gelator molecules has attracted increasing attention owing to their ability to achieve certain functional properties in a designated space at a designated time. Peptides conjugated with hydrophobic moieties are typical examples of supramolecular gelators (low molecular weight gelators, LMWGs), which can be designed or programmed to self-assemble to form nanofibers/nanosheets in response to a broad range of stimuli or microenvironments. In the last decade, several groups have reported that the self-assembly of small gelator molecules achieved inside living cells or on the surfaces of living cells induced selective cell death, which would lead to a novel therapeutic approach or a novel cell selection tool. This focused review outlines the self-assembly of small gelator molecules inside living cells that control cell fate.

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© The Society of Polymer Science, Japan 2020