神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90007733
このアイテムのアクセス数:
9
件
(
2024-04-26
06:38 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90007733 (fulltext)
pdf
713 KB
6
メタデータ
ファイル出力
メタデータID
90007733
アクセス権
open access
出版タイプ
Version of Record
タイトル
Does prophylactic antibiotic administration for tooth extraction affect PT-INR in patients taking warfarin?
著者
Iwata, Eiji ; Tachibana, Akira ; Kusumoto, Junya ; Takata, Naoki ; Hasegawa, Takumi ; Akashi, Masaya
著者名
Iwata, Eiji
岩田, 英治
イワタ, エイジ
著者名
Tachibana, Akira
著者名
Kusumoto, Junya
著者名
Takata, Naoki
著者ID
A1489
研究者ID
1000050546497
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=322ffbb7f3848e30520e17560c007669
著者名
Hasegawa, Takumi
長谷川, 巧実
ハセガワ, タクミ
所属機関名
医学研究科
著者ID
A1492
研究者ID
1000040597168
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b7649a2950dc725a520e17560c007669
著者名
Akashi, Masaya
明石, 昌也
アカシ, マサヤ
所属機関名
医学研究科
収録物名
BMC Oral Health
巻(号)
20(1)
ページ
331-331
出版者
BMC
刊行日
2020-11-19
公開日
2021-01-12
抄録
Background Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. Methods A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. Results Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). Conclusion Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.
キーワード
Antibiotics
Analgesics
Warfarin
Tooth extraction
International normalized ratio
カテゴリ
医学研究科
学術雑誌論文
権利
© The Author(s) 2020.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
詳細を表示
資源タイプ
journal article
言語
English (英語)
eISSN
1472-6831
OPACで所蔵を検索
CiNiiで学外所蔵を検索
NCID
AA11839983
OPACで所蔵を検索
CiNiiで表示
関連情報
DOI
https://doi.org/10.1186/s12903-020-01326-w
ホームへ戻る