神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90007796
このアイテムのアクセス数:
25
件
(
2024-03-29
18:04 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90007796 (fulltext)
pdf
1.40 MB
5
メタデータ
ファイル出力
メタデータID
90007796
アクセス権
open access
出版タイプ
Version of Record
タイトル
Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma
著者
Kubota, Hikaru ; Miyawaki, Daisuke ; Mukumoto, Naritoshi ; Ishihara, Takeaki ; Matsumura, Megumi ; Hasegawa, Takumi ; Akashi, Masaya ; Kiyota, Naomi ; Shinomiya, Hirotaka ; Teshima, Masanori ; Nibu, Ken-ichi ; Sasaki, Ryohei
著者名
Kubota, Hikaru
著者ID
A1427
研究者ID
1000030546502
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.402315425160a86f520e17560c007669.html
著者名
Miyawaki, Daisuke
宮脇, 大輔
ミヤワキ, ダイスケ
所属機関名
医学部附属病院
著者ID
A2247
研究者ID
1000070634278
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.79fcee28d118d94d520e17560c007669.html
著者名
Mukumoto, Naritoshi
椋本, 成俊
ムクモト, ナリトシ
所属機関名
医学部附属病院
著者ID
A1502
研究者ID
1000010546477
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.200899dab15877cf520e17560c007669.html
著者名
Ishihara, Takeaki
石原, 武明
イシハラ, タケアキ
所属機関名
医学部附属病院
著者名
Matsumura, Megumi
著者ID
A1489
研究者ID
1000050546497
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.322ffbb7f3848e30520e17560c007669.html
著者名
Hasegawa, Takumi
長谷川, 巧実
ハセガワ, タクミ
所属機関名
医学研究科
著者ID
A1492
研究者ID
1000040597168
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.b7649a2950dc725a520e17560c007669.html
著者名
Akashi, Masaya
明石, 昌也
アカシ, マサヤ
所属機関名
医学研究科
著者ID
A1407
研究者ID
1000040515037
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.5fd898ae58a689e3520e17560c007669.html
著者名
Kiyota, Naomi
清田, 尚臣
キヨタ, ナオミ
所属機関名
医学部附属病院
著者ID
A1524
研究者ID
1000000725385
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.5db8a2203632bc2d520e17560c007669.html
著者名
Shinomiya, Hirotaka
四宮, 弘隆
シノミヤ, ヒロタカ
所属機関名
医学部附属病院
著者ID
A2108
研究者ID
1000010749146
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.a9b0940d72340373520e17560c007669.html
著者名
Teshima, Masanori
手島, 直則
テシマ, マサノリ
所属機関名
医学部附属病院
著者ID
A0122
研究者ID
1000020251283
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.ea4b7e7966b26726520e17560c007669.html
著者名
Nibu, Ken-ichi
丹生, 健一
ニブ, ケンイチ
所属機関名
医学研究科
著者ID
A1363
研究者ID
1000030346267
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.f5e9afd9968a7ac8520e17560c007669.html
著者名
Sasaki, Ryohei
佐々木, 良平
ササキ, リョウヘイ
所属機関名
医学部附属病院
収録物名
Radiation Oncology
巻(号)
16(1)
ページ
1-1
出版者
BMC
刊行日
2021-01-05
公開日
2021-01-26
抄録
Background To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose–volume histogram (DVH) parameters. Methods We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008–2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy–70 Gy [V10–70]) were investigated and compared between patients with and without ORNJ. The Mann–Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan–Meier analyses were performed for cumulative ORNJ incidence estimation. Results Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3–145) months. The median time to ORNJ development was 27 (range 2–127) months. DVH analysis revealed that V30–V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). Conclusions V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.
キーワード
Osteoradionecrosis of the jaw
Head and neck squamous cell carcinoma
Dose-volume histogram
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© The Author(s) 2020.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
詳細を表示
資源タイプ
journal article
言語
English (英語)
eISSN
1748-717X
OPACで所蔵を検索
CiNiiで学外所蔵を検索
関連情報
DOI
https://doi.org/10.1186/s13014-020-01701-5
ホームへ戻る