神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90007830
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2024-03-29
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90007830 (fulltext)
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メタデータID
90007830
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open access
出版タイプ
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タイトル
The impact of antibiotics on the metabolic status of obese adults without bacterial infection: a systematic review and meta-analysis
著者
Yoshida, Naofumi ; Saito, Yoshihiro ; Tsujimoto, Yasushi ; Taito, Shunsuke ; Banno, Masahiro ; Kataoka, Yuki ; Yamashita, Tomoya ; Hirata, Ken-ichi
著者名
Yoshida, Naofumi
吉田, 尚史
ヨシダ, ナオフミ
著者名
Saito, Yoshihiro
著者名
Tsujimoto, Yasushi
著者名
Taito, Shunsuke
著者名
Banno, Masahiro
著者名
Kataoka, Yuki
著者ID
A1385
研究者ID
1000090437468
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.6d54da470683693a520e17560c007669.html
著者名
Yamashita, Tomoya
山下, 智也
ヤマシタ, トモヤ
所属機関名
医学部附属病院
著者ID
A0883
研究者ID
1000020283880
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.383af6bc2b817735520e17560c007669.html
著者名
Hirata, Ken-ichi
平田, 健一
ヒラタ, ケンイチ
所属機関名
医学研究科
収録物名
Annals of Translational Medicine
巻(号)
8(17)
ページ
1059-1059
出版者
AME Publishing Company
刊行日
2020-09
公開日
2021-02-04
抄録
Background: The gut microbiota is involved in the pathophysiology of obesity. It is known that oral antibiotics manipulate the gut microbiota; however, the impact on host metabolism of obese adults without bacterial infection has not been systematically summarized. Methods: We searched for randomized, placebo-controlled trials that investigated the effects of oral antibiotics on the metabolic status in obese adults via Medline, EMBASE, and the Cochrane Library. Primary outcomes were homeostasis model assessment of insulin resistance (HOMA-IR), body weight, and rate of diarrhea. Additional outcomes included fasting plasma glucose (FPG), plasma glucagon-like peptide-1 (GLP-1), waist circumference, fecal short-chain fatty acid (SCFA) levels, and all adverse events. We assessed the certainty of evidence based on Grading of Recommendations, Assessment, Development and Evaluations. Results: Among 1,762 articles screened, four studies were eligible for quantitative analysis, two of which were applied to meta-analysis. Oral antibiotics had low influence on HOMA-IR [mean difference (MD) 0.09 (95% CI: −0.96 to 1.13)], body weight [MD 4.1 kg (95% CI: −23.77 to 31.97)], FPG [MD −0.12 mmol/L (95% CI: −0.47 to 0.23)], and GLP-1 [MD 0.20 pmol/L (95% CI: −2.36 to 2.76)] compared to placebo. Antibiotics treatment altered fecal acetate and butyrate levels, but resulted in little difference in propionate levels [MD −13.60 µmol/g (95% CI: −22.43 to −4.77), MD −7.60 µmol/g (−10.97 to −4.23), MD −1.10 µmol/g (95% CI: −4.18 to 1.98), respectively]. Several adverse events, such as sun sensitivity and gastrointestinal discomfort, were reported following antibiotics treatment, but no diarrhea. The certainty of evidence for most outcomes was very low to low, except for fecal SCFAs. Conclusions: Our results indicate that oral antibiotics treatment is insufficient to ameliorate metabolic parameters in obese adults, suggesting that oral antibiotics treatment may not qualify as a therapeutic approach for obesity.
キーワード
Overweight
antibiotics
systematic review
meta-analysis
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© Annals of Translational Medicine. All rights reserved.
This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0).
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資源タイプ
journal article
言語
English (英語)
ISSN
2305-5839
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eISSN
2305-5847
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関連情報
DOI
https://doi.org/10.21037/atm-20-1007a
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